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Approach to vaccinating the pediatric solid organ transplant candidate and recipient

Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural i...

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Autores principales: Kao, Carol M., Michaels, Marian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663229/
https://www.ncbi.nlm.nih.gov/pubmed/38027303
http://dx.doi.org/10.3389/fped.2023.1271065
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author Kao, Carol M.
Michaels, Marian G.
author_facet Kao, Carol M.
Michaels, Marian G.
author_sort Kao, Carol M.
collection PubMed
description Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural immunity to pathogens from community exposures. Multiple society guidelines exist for vaccination of SOT candidate and recipients, although challenges remain given limited safety and efficacy data available for pediatric SOT recipients, particularly for live-vaccines. After transplant, individual patient nuances regarding exposure risks and net state of immunosuppression will impact timing of immunizations. The purpose of this review is to provide readers with a concise, practical, expert-opinion on the approach to vaccinating the SOT candidate and recipient and to supplement existing guidelines. In addition, pediatric-specific knowledge gaps in the field and future research priorities will be highlighted.
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spelling pubmed-106632292023-11-08 Approach to vaccinating the pediatric solid organ transplant candidate and recipient Kao, Carol M. Michaels, Marian G. Front Pediatr Pediatrics Solid organ transplantation (SOT) candidates and recipients are at increased risk for morbidity and mortality from vaccine-preventable infections. Children are at particular risk given that they may not have completed their primary immunization series at time of transplant or have acquired natural immunity to pathogens from community exposures. Multiple society guidelines exist for vaccination of SOT candidate and recipients, although challenges remain given limited safety and efficacy data available for pediatric SOT recipients, particularly for live-vaccines. After transplant, individual patient nuances regarding exposure risks and net state of immunosuppression will impact timing of immunizations. The purpose of this review is to provide readers with a concise, practical, expert-opinion on the approach to vaccinating the SOT candidate and recipient and to supplement existing guidelines. In addition, pediatric-specific knowledge gaps in the field and future research priorities will be highlighted. Frontiers Media S.A. 2023-11-08 /pmc/articles/PMC10663229/ /pubmed/38027303 http://dx.doi.org/10.3389/fped.2023.1271065 Text en © 2023 Kao and Michaels. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Kao, Carol M.
Michaels, Marian G.
Approach to vaccinating the pediatric solid organ transplant candidate and recipient
title Approach to vaccinating the pediatric solid organ transplant candidate and recipient
title_full Approach to vaccinating the pediatric solid organ transplant candidate and recipient
title_fullStr Approach to vaccinating the pediatric solid organ transplant candidate and recipient
title_full_unstemmed Approach to vaccinating the pediatric solid organ transplant candidate and recipient
title_short Approach to vaccinating the pediatric solid organ transplant candidate and recipient
title_sort approach to vaccinating the pediatric solid organ transplant candidate and recipient
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663229/
https://www.ncbi.nlm.nih.gov/pubmed/38027303
http://dx.doi.org/10.3389/fped.2023.1271065
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