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The oral-gut-circulatory axis: from homeostasis to colon cancer

The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing...

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Detalles Bibliográficos
Autores principales: Tortora, Sofia C., Agurto, Maria Gonzalez, Martello, Laura A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663299/
https://www.ncbi.nlm.nih.gov/pubmed/38029267
http://dx.doi.org/10.3389/fcimb.2023.1289452
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author Tortora, Sofia C.
Agurto, Maria Gonzalez
Martello, Laura A.
author_facet Tortora, Sofia C.
Agurto, Maria Gonzalez
Martello, Laura A.
author_sort Tortora, Sofia C.
collection PubMed
description The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer.
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spelling pubmed-106632992023-01-01 The oral-gut-circulatory axis: from homeostasis to colon cancer Tortora, Sofia C. Agurto, Maria Gonzalez Martello, Laura A. Front Cell Infect Microbiol Cellular and Infection Microbiology The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer. Frontiers Media S.A. 2023-11-08 /pmc/articles/PMC10663299/ /pubmed/38029267 http://dx.doi.org/10.3389/fcimb.2023.1289452 Text en Copyright © 2023 Tortora, Agurto and Martello https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Tortora, Sofia C.
Agurto, Maria Gonzalez
Martello, Laura A.
The oral-gut-circulatory axis: from homeostasis to colon cancer
title The oral-gut-circulatory axis: from homeostasis to colon cancer
title_full The oral-gut-circulatory axis: from homeostasis to colon cancer
title_fullStr The oral-gut-circulatory axis: from homeostasis to colon cancer
title_full_unstemmed The oral-gut-circulatory axis: from homeostasis to colon cancer
title_short The oral-gut-circulatory axis: from homeostasis to colon cancer
title_sort oral-gut-circulatory axis: from homeostasis to colon cancer
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663299/
https://www.ncbi.nlm.nih.gov/pubmed/38029267
http://dx.doi.org/10.3389/fcimb.2023.1289452
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