Cargando…
The oral-gut-circulatory axis: from homeostasis to colon cancer
The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663299/ https://www.ncbi.nlm.nih.gov/pubmed/38029267 http://dx.doi.org/10.3389/fcimb.2023.1289452 |
_version_ | 1785138368759201792 |
---|---|
author | Tortora, Sofia C. Agurto, Maria Gonzalez Martello, Laura A. |
author_facet | Tortora, Sofia C. Agurto, Maria Gonzalez Martello, Laura A. |
author_sort | Tortora, Sofia C. |
collection | PubMed |
description | The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer. |
format | Online Article Text |
id | pubmed-10663299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106632992023-01-01 The oral-gut-circulatory axis: from homeostasis to colon cancer Tortora, Sofia C. Agurto, Maria Gonzalez Martello, Laura A. Front Cell Infect Microbiol Cellular and Infection Microbiology The human microbiota is widely recognized as providing crucial health benefits to its host, specifically by modulating immune homeostasis. Microbial imbalance, known as dysbiosis, is linked to several conditions in the body. The oral cavity and gut host the two largest microbial communities playing a major role in microbial-associated diseases. While the oral-gut axis has been previously explored, our review uniquely highlights the significance of incorporating the circulatory system into this axis. The interaction between immune cells, inflammatory factors, circulating bacteria, and microbial metabolites influences the homeostasis of both the oral and gut microbiota in a bidirectional manner. In this comprehensive review, we aim to describe the bacterial components of the oral-gut-circulatory axis in both health and disease, with a specific focus on colon cancer. Frontiers Media S.A. 2023-11-08 /pmc/articles/PMC10663299/ /pubmed/38029267 http://dx.doi.org/10.3389/fcimb.2023.1289452 Text en Copyright © 2023 Tortora, Agurto and Martello https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Tortora, Sofia C. Agurto, Maria Gonzalez Martello, Laura A. The oral-gut-circulatory axis: from homeostasis to colon cancer |
title | The oral-gut-circulatory axis: from homeostasis to colon cancer |
title_full | The oral-gut-circulatory axis: from homeostasis to colon cancer |
title_fullStr | The oral-gut-circulatory axis: from homeostasis to colon cancer |
title_full_unstemmed | The oral-gut-circulatory axis: from homeostasis to colon cancer |
title_short | The oral-gut-circulatory axis: from homeostasis to colon cancer |
title_sort | oral-gut-circulatory axis: from homeostasis to colon cancer |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663299/ https://www.ncbi.nlm.nih.gov/pubmed/38029267 http://dx.doi.org/10.3389/fcimb.2023.1289452 |
work_keys_str_mv | AT tortorasofiac theoralgutcirculatoryaxisfromhomeostasistocoloncancer AT agurtomariagonzalez theoralgutcirculatoryaxisfromhomeostasistocoloncancer AT martellolauraa theoralgutcirculatoryaxisfromhomeostasistocoloncancer AT tortorasofiac oralgutcirculatoryaxisfromhomeostasistocoloncancer AT agurtomariagonzalez oralgutcirculatoryaxisfromhomeostasistocoloncancer AT martellolauraa oralgutcirculatoryaxisfromhomeostasistocoloncancer |