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The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas

Next generation sequencing (NGS) is a technology that broadens the horizon of knowledge of several somatic pathologies, especially in oncological and oncohematological pathology. In the case of NHL, the understanding of the mechanisms of tumorigenesis, tumor proliferation and the identification of g...

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Autores principales: Tomacinschii, Victor, Mosquera Orgueira, Adrian, Santos, Carlos Aliste, Robu, Maria, Buruiana, Sanda, Fraga Rodriguez, Maximo Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663367/
https://www.ncbi.nlm.nih.gov/pubmed/38023160
http://dx.doi.org/10.3389/fonc.2023.1275327
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author Tomacinschii, Victor
Mosquera Orgueira, Adrian
Santos, Carlos Aliste
Robu, Maria
Buruiana, Sanda
Fraga Rodriguez, Maximo Francisco
author_facet Tomacinschii, Victor
Mosquera Orgueira, Adrian
Santos, Carlos Aliste
Robu, Maria
Buruiana, Sanda
Fraga Rodriguez, Maximo Francisco
author_sort Tomacinschii, Victor
collection PubMed
description Next generation sequencing (NGS) is a technology that broadens the horizon of knowledge of several somatic pathologies, especially in oncological and oncohematological pathology. In the case of NHL, the understanding of the mechanisms of tumorigenesis, tumor proliferation and the identification of genetic markers specific to different lymphoma subtypes led to more accurate classification and diagnosis. Similarly, the data obtained through NGS allowed the identification of recurrent somatic mutations that can serve as therapeutic targets that can be inhibited and thus reducing the rate of resistant cases. The article’s purpose is to offer a comprehensive overview of the best ways of integrating of next-generation sequencing technologies for diagnosis, prognosis, classification, and selection of optimal therapy from the perspective of tailor-made medicine.
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spelling pubmed-106633672023-01-01 The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas Tomacinschii, Victor Mosquera Orgueira, Adrian Santos, Carlos Aliste Robu, Maria Buruiana, Sanda Fraga Rodriguez, Maximo Francisco Front Oncol Oncology Next generation sequencing (NGS) is a technology that broadens the horizon of knowledge of several somatic pathologies, especially in oncological and oncohematological pathology. In the case of NHL, the understanding of the mechanisms of tumorigenesis, tumor proliferation and the identification of genetic markers specific to different lymphoma subtypes led to more accurate classification and diagnosis. Similarly, the data obtained through NGS allowed the identification of recurrent somatic mutations that can serve as therapeutic targets that can be inhibited and thus reducing the rate of resistant cases. The article’s purpose is to offer a comprehensive overview of the best ways of integrating of next-generation sequencing technologies for diagnosis, prognosis, classification, and selection of optimal therapy from the perspective of tailor-made medicine. Frontiers Media S.A. 2023-11-08 /pmc/articles/PMC10663367/ /pubmed/38023160 http://dx.doi.org/10.3389/fonc.2023.1275327 Text en Copyright © 2023 Tomacinschii, Mosquera Orgueira, Santos, Robu, Buruiana and Fraga Rodriguez https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Tomacinschii, Victor
Mosquera Orgueira, Adrian
Santos, Carlos Aliste
Robu, Maria
Buruiana, Sanda
Fraga Rodriguez, Maximo Francisco
The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
title The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
title_full The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
title_fullStr The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
title_full_unstemmed The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
title_short The implication of next-generation sequencing in the diagnosis and clinical management of non-Hodgkin lymphomas
title_sort implication of next-generation sequencing in the diagnosis and clinical management of non-hodgkin lymphomas
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663367/
https://www.ncbi.nlm.nih.gov/pubmed/38023160
http://dx.doi.org/10.3389/fonc.2023.1275327
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