PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling

TANK-binding kinase 1 (TBK1) is a key kinase in regulating antiviral innate immune responses. While the oligomerization of TBK1 is critical for its full activation, the molecular mechanism of how TBK1 forms oligomers remains unclear. Here, we show that protein tyrosine kinase 2 beta (PTK2B) acts as...

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Detalles Bibliográficos
Autores principales: Lin, Yongfang, Yang, Jing, Yang, Qili, Zeng, Sha, Zhang, Jiayu, Zhu, Yuanxiang, Tong, Yuxin, Li, Lin, Tan, Weiqi, Chen, Dahua, Sun, Qinmiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663505/
https://www.ncbi.nlm.nih.gov/pubmed/37989995
http://dx.doi.org/10.1038/s41467-023-43419-4

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