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SETD2 deficiency accelerates sphingomyelin accumulation and promotes the development of renal cancer

Patients with polycystic kidney disease (PKD) encounter a high risk of clear cell renal cell carcinoma (ccRCC), a malignant tumor with dysregulated lipid metabolism. SET domain–containing 2 (SETD2) has been identified as an important tumor suppressor and an immunosuppressor in ccRCC. However, the ro...

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Detalles Bibliográficos
Autores principales:	Rao, Hanyu, Liu, Changwei, Wang, Aiting, Ma, Chunxiao, Xu, Yue, Ye, Tianbao, Su, Wenqiong, Zhou, Peijun, Gao, Wei-Qiang, Li, Li, Ding, Xianting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663509/ https://www.ncbi.nlm.nih.gov/pubmed/37989747 http://dx.doi.org/10.1038/s41467-023-43378-w

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