Structure and function of the membrane microdomains in osteoclasts

The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdom...

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Autores principales: Hou, Jialong, Liu, Jian, Huang, Zhixian, Wang, Yining, Yao, Hanbing, Hu, Zhenxin, Shi, Chengge, Xu, Jiake, Wang, Qingqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663511/
https://www.ncbi.nlm.nih.gov/pubmed/37989999
http://dx.doi.org/10.1038/s41413-023-00294-5
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author Hou, Jialong
Liu, Jian
Huang, Zhixian
Wang, Yining
Yao, Hanbing
Hu, Zhenxin
Shi, Chengge
Xu, Jiake
Wang, Qingqing
author_facet Hou, Jialong
Liu, Jian
Huang, Zhixian
Wang, Yining
Yao, Hanbing
Hu, Zhenxin
Shi, Chengge
Xu, Jiake
Wang, Qingqing
author_sort Hou, Jialong
collection PubMed
description The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle.
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spelling pubmed-106635112023-11-21 Structure and function of the membrane microdomains in osteoclasts Hou, Jialong Liu, Jian Huang, Zhixian Wang, Yining Yao, Hanbing Hu, Zhenxin Shi, Chengge Xu, Jiake Wang, Qingqing Bone Res Review Article The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle. Nature Publishing Group UK 2023-11-21 /pmc/articles/PMC10663511/ /pubmed/37989999 http://dx.doi.org/10.1038/s41413-023-00294-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Hou, Jialong
Liu, Jian
Huang, Zhixian
Wang, Yining
Yao, Hanbing
Hu, Zhenxin
Shi, Chengge
Xu, Jiake
Wang, Qingqing
Structure and function of the membrane microdomains in osteoclasts
title Structure and function of the membrane microdomains in osteoclasts
title_full Structure and function of the membrane microdomains in osteoclasts
title_fullStr Structure and function of the membrane microdomains in osteoclasts
title_full_unstemmed Structure and function of the membrane microdomains in osteoclasts
title_short Structure and function of the membrane microdomains in osteoclasts
title_sort structure and function of the membrane microdomains in osteoclasts
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663511/
https://www.ncbi.nlm.nih.gov/pubmed/37989999
http://dx.doi.org/10.1038/s41413-023-00294-5
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