Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact

KEY CLINICAL MESSAGE: EDTA‐dependent pseudothrombocytopenia as well as myelosuppression should be suspected when thrombocytopenia occurs in patients with autoimmune disease during chemotherapy. ABSTRACT: A patient with pancreatic cancer and ulcerative colitis developed transient ethylenediaminetetra...

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Autores principales: Watanabe, Ayako, Toshima, Hirokazu, Saeki, Misa, Nagata, Takuya, Koyanagi, Tatsuo, Minamizawa, Masumi, Kashiwabara, Yuka, Kobayashi, Koji, Shimada, Ken, Momo, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663534/
https://www.ncbi.nlm.nih.gov/pubmed/38028043
http://dx.doi.org/10.1002/ccr3.8153
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author Watanabe, Ayako
Toshima, Hirokazu
Saeki, Misa
Nagata, Takuya
Koyanagi, Tatsuo
Minamizawa, Masumi
Kashiwabara, Yuka
Kobayashi, Koji
Shimada, Ken
Momo, Kenji
author_facet Watanabe, Ayako
Toshima, Hirokazu
Saeki, Misa
Nagata, Takuya
Koyanagi, Tatsuo
Minamizawa, Masumi
Kashiwabara, Yuka
Kobayashi, Koji
Shimada, Ken
Momo, Kenji
author_sort Watanabe, Ayako
collection PubMed
description KEY CLINICAL MESSAGE: EDTA‐dependent pseudothrombocytopenia as well as myelosuppression should be suspected when thrombocytopenia occurs in patients with autoimmune disease during chemotherapy. ABSTRACT: A patient with pancreatic cancer and ulcerative colitis developed transient ethylenediaminetetraacetic acid (EDTA)‐dependent pseudothrombocytopenia with exacerbation of ulcerative colitis during chemotherapy. Unfortunately, pseudothrombocytopenia could not be immediately detected because thrombocytopenia was masked by a reasonable time course of adverse events associated with chemotherapy and ulcerative colitis recurrence. When thrombocytopenia occurs during chemotherapy, especially in patients with autoimmune diseases, EDTA‐dependent pseudothrombocytopenia and bone marrow suppression caused by anti‐cancer agents should be suspected.
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spelling pubmed-106635342023-11-21 Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact Watanabe, Ayako Toshima, Hirokazu Saeki, Misa Nagata, Takuya Koyanagi, Tatsuo Minamizawa, Masumi Kashiwabara, Yuka Kobayashi, Koji Shimada, Ken Momo, Kenji Clin Case Rep Case Report KEY CLINICAL MESSAGE: EDTA‐dependent pseudothrombocytopenia as well as myelosuppression should be suspected when thrombocytopenia occurs in patients with autoimmune disease during chemotherapy. ABSTRACT: A patient with pancreatic cancer and ulcerative colitis developed transient ethylenediaminetetraacetic acid (EDTA)‐dependent pseudothrombocytopenia with exacerbation of ulcerative colitis during chemotherapy. Unfortunately, pseudothrombocytopenia could not be immediately detected because thrombocytopenia was masked by a reasonable time course of adverse events associated with chemotherapy and ulcerative colitis recurrence. When thrombocytopenia occurs during chemotherapy, especially in patients with autoimmune diseases, EDTA‐dependent pseudothrombocytopenia and bone marrow suppression caused by anti‐cancer agents should be suspected. John Wiley and Sons Inc. 2023-11-21 /pmc/articles/PMC10663534/ /pubmed/38028043 http://dx.doi.org/10.1002/ccr3.8153 Text en © 2023 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Watanabe, Ayako
Toshima, Hirokazu
Saeki, Misa
Nagata, Takuya
Koyanagi, Tatsuo
Minamizawa, Masumi
Kashiwabara, Yuka
Kobayashi, Koji
Shimada, Ken
Momo, Kenji
Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
title Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
title_full Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
title_fullStr Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
title_full_unstemmed Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
title_short Transient EDTA‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact
title_sort transient edta‐dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: a case of misleading platelet count results attributable to a laboratory artifact
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663534/
https://www.ncbi.nlm.nih.gov/pubmed/38028043
http://dx.doi.org/10.1002/ccr3.8153
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