Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants of concern. Host proteases, TMPRSS2 and CTSL/CTSB cleave the SARS-CoV-2 spike to play a...

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Detalles Bibliográficos
Autores principales: Wang, Haofeng, Yang, Qi, Liu, Xiaoce, Xu, Zili, Shao, Maolin, Li, Dongxu, Duan, Yinkai, Tang, Jielin, Yu, Xianqiang, Zhang, Yumin, Hao, Aihua, Wang, Yajie, Chen, Jie, Zhu, Chenghao, Guddat, Luke, Chen, Hongli, Zhang, Leike, Chen, Xinwen, Jiang, Biao, Sun, Lei, Rao, Zihe, Yang, Haitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663540/
https://www.ncbi.nlm.nih.gov/pubmed/37990007
http://dx.doi.org/10.1038/s41467-023-42527-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663540/
https://www.ncbi.nlm.nih.gov/pubmed/37990007
http://dx.doi.org/10.1038/s41467-023-42527-5

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