Cargando…

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants of concern. Host proteases, TMPRSS2 and CTSL/CTSB cleave the SARS-CoV-2 spike to play a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Haofeng, Yang, Qi, Liu, Xiaoce, Xu, Zili, Shao, Maolin, Li, Dongxu, Duan, Yinkai, Tang, Jielin, Yu, Xianqiang, Zhang, Yumin, Hao, Aihua, Wang, Yajie, Chen, Jie, Zhu, Chenghao, Guddat, Luke, Chen, Hongli, Zhang, Leike, Chen, Xinwen, Jiang, Biao, Sun, Lei, Rao, Zihe, Yang, Haitao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663540/ https://www.ncbi.nlm.nih.gov/pubmed/37990007 http://dx.doi.org/10.1038/s41467-023-42527-5

Ejemplares similares

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332
por: Zhao, Yao, et al.
Publicado: (2021)

The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2
por: Jin, Zhenming, et al.
Publicado: (2021)

Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2
por: Zhao, Yao, et al.
Publicado: (2022)

High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors
por: Zhao, Yao, et al.
Publicado: (2021)

Conformational Changes in a Macrolide Antibiotic Binding Protein From Mycobacterium smegmatis Upon ADP Binding
por: Zhang, Qingqing, et al.
Publicado: (2021)

Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy
por: Cao, Lin, et al.
Publicado: (2018)

Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC
por: Liu, Fengjiang, et al.
Publicado: (2020)

Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis: a new antibiotic resistance drug target
por: Zhang, Qingqing, et al.
Publicado: (2018)

Structural insights into substrate recognition by the type VII secretion system
por: Wang, Shuhui, et al.
Publicado: (2019)

Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase
por: Wang, Quan, et al.
Publicado: (2020)

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis
por: Yan, Liming, et al.
Publicado: (2021)

Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC
por: Liang, Jingxi, et al.
Publicado: (2023)

Cryo-EM structures of a prokaryotic heme transporter CydDC
por: Zhu, Chen, et al.
Publicado: (2023)

Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB
por: Sun, Shan, et al.
Publicado: (2022)

Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library
por: Wang, Peilin, et al.
Publicado: (2018)

Crystal structure of monkeypox H1 phosphatase, an antiviral drug target
por: Cui, Wen, et al.
Publicado: (2022)

Structure of the RNA-dependent RNA polymerase from COVID-19 virus
por: Gao, Yan, et al.
Publicado: (2020)

Mycobacterial dynamin-like protein IniA mediates membrane fission
por: Wang, Manfu, et al.
Publicado: (2019)

Synthesis and Evaluation of Reactive Oxygen Species Sensitive Prodrugs of a NAMPT Inhibitor FK866
por: Xu, Zili, et al.
Publicado: (2022)

Recent progress in the discovery of inhibitors targeting coronavirus proteases
por: Wang, Haofeng, et al.
Publicado: (2016)

Attachment, Entry, and Intracellular Trafficking of Classical Swine Fever Virus
por: Guo, Xin, et al.
Publicado: (2023)

Histone deacetylase 4 inhibits NF-κB activation by facilitating IκBα sumoylation
por: Yang, Qi, et al.
Publicado: (2021)

Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels
por: Wang, Weiwei, et al.
Publicado: (2021)

Structural biology of SARS-CoV-2 and implications for therapeutic development
por: Yang, Haitao, et al.
Publicado: (2021)

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives
por: Amporndanai, Kangsa, et al.
Publicado: (2021)

Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-κB signaling
por: Xu, Chonghui, et al.
Publicado: (2021)

Entry Properties and Entry Inhibitors of a Human H7N9 Influenza Virus
por: Si, Youhui, et al.
Publicado: (2014)

The metabolic responses to hepatitis B virus infection shed new light on pathogenesis and targets for treatment
por: Li, Hongde, et al.
Publicado: (2015)

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2)
por: Zhang, Lu, et al.
Publicado: (2020)

Molecular mechanism of ensitrelvir inhibiting SARS-CoV-2 main protease and its variants
por: Lin, Mengmeng, et al.
Publicado: (2023)

Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates
por: Zhou, Shan, et al.
Publicado: (2021)

Broad Host Tropism of Flaviviruses during the Entry Stage
por: Zhang, Yanan, et al.
Publicado: (2023)

Real-time Imaging of Rabies Virus Entry into Living Vero cells
por: Xu, Haijiao, et al.
Publicado: (2015)

Structural characterization of the HCoV-229E fusion core
por: Zhang, Wei, et al.
Publicado: (2018)

Watershed Horizontal Ecological Compensation Policy and Green Ecological City Development: Spatial and Mechanism Assessment
por: Lin, Xinwen, et al.
Publicado: (2023)

CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus
por: Zhang, Leike, et al.
Publicado: (2023)

T-Cell Immunoglobulin and Mucin Domain 1 (TIM-1) Is a Functional Entry Factor for Tick-Borne Encephalitis Virus
por: Zhang, Xiaowei, et al.
Publicado: (2022)

Rural and Female Patients with Old Myocardial Infarction Lacked Knowledge and Preventive Measures During the Beginning of the COVID-19 Epidemic in Chongqing, Southwest China
por: Cao, Maolin, et al.
Publicado: (2021)

Development of a novel virus-like particle-based vaccine for preventing tick-borne encephalitis virus infection
por: Tang, Jielin, et al.
Publicado: (2023)

Structural insights into SARS coronavirus proteins
por: Bartlam, Mark, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_cch4iolvfnui318anb6a3vs36u