Targetable lesions and proteomes predict therapy sensitivity through disease evolution in pediatric acute lymphoblastic leukemia

Childhood acute lymphoblastic leukemia (ALL) genomes show that relapses often arise from subclonal outgrowths. However, the impact of clonal evolution on the actionable proteome and response to targeted therapy is not known. Here, we present a comprehensive retrospective analysis of paired ALL diagn...

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Detalles Bibliográficos
Autores principales: Lorentzian, Amanda C., Rever, Jenna, Ergin, Enes K., Guo, Meiyun, Akella, Neha M., Rolf, Nina, James Lim, C., Reid, Gregor S. D., Maxwell, Christopher A., Lange, Philipp F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663560/
https://www.ncbi.nlm.nih.gov/pubmed/37989729
http://dx.doi.org/10.1038/s41467-023-42701-9

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