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The structure of the teleost Immunoglobulin M core provides insights on polymeric antibody evolution, assembly, and function

Polymeric (p) immunoglobulins (Igs) serve broad functions during vertebrate immune responses. Typically, pIgs contain between two and six Ig monomers, each with two antigen binding fragments and one fragment crystallization (Fc). In addition, many pIgs assemble with a joining-chain (JC); however, th...

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Detalles Bibliográficos
Autores principales: Lyu, Mengfan, Malyutin, Andrey G., Stadtmueller, Beth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663602/
https://www.ncbi.nlm.nih.gov/pubmed/37989996
http://dx.doi.org/10.1038/s41467-023-43240-z