Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

Choline is an essential nutrient, and its deficiency causes steatohepatitis. Dietary phosphatidylcholine (PC) is digested into lysoPC (LPC), glycerophosphocholine, and choline in the intestinal lumen and is the primary source of systemic choline. However, the major PC metabolites absorbed in the int...

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Detalles Bibliográficos
Autores principales: Tamura, Ryutaro, Sabu, Yusuke, Mizuno, Tadahaya, Mizuno, Seiya, Nakano, Satoshi, Suzuki, Mitsuyoshi, Abukawa, Daiki, Kaji, Shunsaku, Azuma, Yoshihiro, Inui, Ayano, Okamoto, Tatsuya, Shimizu, Seiichi, Fukuda, Akinari, Sakamoto, Seisuke, Kasahara, Mureo, Takahashi, Satoru, Kusuhara, Hiroyuki, Zen, Yoh, Ando, Tomohiro, Hayashi, Hisamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663612/
https://www.ncbi.nlm.nih.gov/pubmed/37990006
http://dx.doi.org/10.1038/s41467-023-42424-x

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