Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a progressive disease in which pulmonary arterial (PA) endothelial cell (EC) dysfunction is associated with unrepaired DNA damage. BMPR2 is the most common genetic cause of PAH. We report that human PAEC with reduced BMPR2 have persistent DNA damage in room a...

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Detalles Bibliográficos
Autores principales: Isobe, Sarasa, Nair, Ramesh V., Kang, Helen Y., Wang, Lingli, Moonen, Jan-Renier, Shinohara, Tsutomu, Cao, Aiqin, Taylor, Shalina, Otsuki, Shoichiro, Marciano, David P., Harper, Rebecca L., Adil, Mir S., Zhang, Chongyang, Lago-Docampo, Mauro, Körbelin, Jakob, Engreitz, Jesse M., Snyder, Michael P., Rabinovitch, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663616/
https://www.ncbi.nlm.nih.gov/pubmed/37989727
http://dx.doi.org/10.1038/s41467-023-43039-y

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