High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

OBJECTIVE: Thioesterase superfamily member 1 (Them1) is a long chain acyl-CoA thioesterase comprising two N-terminal HotDog fold enzymatic domains linked to a C-terminal lipid-sensing steroidogenic acute regulatory transfer-related (START) domain, which allosterically modulates enzymatic activity. T...

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Detalles Bibliográficos
Autores principales: Krumm, Christopher S., Landzberg, Renée S., Ramos-Espiritu, Lavoisier, Adura, Carolina, Liu, Xu, Acuna, Mariana, Xie, Yang, Xu, Xu, Tillman, Matthew C., Li, Yingxia, Glickman, J. Fraser, Ortlund, Eric A., Ginn, John D., Cohen, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663673/
http://dx.doi.org/10.1016/j.molmet.2023.101832

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