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Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2

VEGFR-2 is a significant target in cancer treatment, inhibiting angiogenesis and impeding tumor growth. Utilizing the essential pharmacophoric structural properties, a new semi-synthetic theobromine analogue (T-1-MBHEPA) was designed as VEGFR-2 inhibitor. Firstly, T-1-MBHEPA's stability and rea...

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Detalles Bibliográficos
Autores principales:	Eissa, Ibrahim H., Yousef, Reda G., Asmaey, Mostafa A., Elkady, Hazem, Husein, Dalal Z., Alsfouk, Aisha A., Ibrahim, Ibrahim M., Elkady, Mohamed A., Elkaeed, Eslam B., Metwaly, Ahmed M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663924/ https://www.ncbi.nlm.nih.gov/pubmed/38028225 http://dx.doi.org/10.1016/j.jsps.2023.101852

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