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Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis

Atherosclerosis as a chronic inflammatory disorder is accompanied with oxidative stress which causes a high morbidity and mortality. Adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, are amongst the most...

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Autores principales: Ebrahimi, Farnaz, Ghazimoradi, Mohammad Mahdi, Fatima, Ghizal, Bahramsoltani, Roodabeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663934/
https://www.ncbi.nlm.nih.gov/pubmed/38028000
http://dx.doi.org/10.1016/j.heliyon.2023.e21849
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author Ebrahimi, Farnaz
Ghazimoradi, Mohammad Mahdi
Fatima, Ghizal
Bahramsoltani, Roodabeh
author_facet Ebrahimi, Farnaz
Ghazimoradi, Mohammad Mahdi
Fatima, Ghizal
Bahramsoltani, Roodabeh
author_sort Ebrahimi, Farnaz
collection PubMed
description Atherosclerosis as a chronic inflammatory disorder is accompanied with oxidative stress which causes a high morbidity and mortality. Adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, are amongst the most important contributors in atherosclerosis. In such cases, dietary interventions with functional foods containing natural antioxidant and anti-inflammatory constituents are of a great interest. Citrus fruits are rich sources of flavonoids as natural pigments with potent antioxidant and anti-inflammatory activities. This study aims to review current evidence regarding the role of citrus flavonoids in the management of atherosclerosis with a focus on their effect on adhesion molecules. Electronic databases including PubMed, Scopus, and Web of Science were searched with the names of adhesion molecules and flavonoids from inception until January 2023. The included articles highly support the beneficial effects of citrus flavonoids in preclinical models of atherosclerosis. Quercetin, naringin and naringenin, hesperidin and hesperetin, nobiletin, rutin, luteolin, apigenin, and kaempferol are the most common flavonoids in citrus fruits which could modulate adhesion molecules including ICAM-1, VCAM-1, E-selectin, and P-selectin. Additionally, markers of chronic inflammation such as interleukins, tumor necrosis factor-α, nuclear factor-κB, and nitric oxide signaling, as well as oxidative stress markers like superoxide dismutase and glutathione were all normalized upon administration of citrus flavonoids. Conclusively, this review confirms the modulatory role of flavonoids on adhesion molecules in atherosclerosis based on the preclinical evaluations. Thus, citrus fruits can be further studied in atherosclerotic patients regarding their activity in reducing adhesion molecules.
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spelling pubmed-106639342023-11-04 Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis Ebrahimi, Farnaz Ghazimoradi, Mohammad Mahdi Fatima, Ghizal Bahramsoltani, Roodabeh Heliyon Review Article Atherosclerosis as a chronic inflammatory disorder is accompanied with oxidative stress which causes a high morbidity and mortality. Adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, are amongst the most important contributors in atherosclerosis. In such cases, dietary interventions with functional foods containing natural antioxidant and anti-inflammatory constituents are of a great interest. Citrus fruits are rich sources of flavonoids as natural pigments with potent antioxidant and anti-inflammatory activities. This study aims to review current evidence regarding the role of citrus flavonoids in the management of atherosclerosis with a focus on their effect on adhesion molecules. Electronic databases including PubMed, Scopus, and Web of Science were searched with the names of adhesion molecules and flavonoids from inception until January 2023. The included articles highly support the beneficial effects of citrus flavonoids in preclinical models of atherosclerosis. Quercetin, naringin and naringenin, hesperidin and hesperetin, nobiletin, rutin, luteolin, apigenin, and kaempferol are the most common flavonoids in citrus fruits which could modulate adhesion molecules including ICAM-1, VCAM-1, E-selectin, and P-selectin. Additionally, markers of chronic inflammation such as interleukins, tumor necrosis factor-α, nuclear factor-κB, and nitric oxide signaling, as well as oxidative stress markers like superoxide dismutase and glutathione were all normalized upon administration of citrus flavonoids. Conclusively, this review confirms the modulatory role of flavonoids on adhesion molecules in atherosclerosis based on the preclinical evaluations. Thus, citrus fruits can be further studied in atherosclerotic patients regarding their activity in reducing adhesion molecules. Elsevier 2023-11-04 /pmc/articles/PMC10663934/ /pubmed/38028000 http://dx.doi.org/10.1016/j.heliyon.2023.e21849 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Ebrahimi, Farnaz
Ghazimoradi, Mohammad Mahdi
Fatima, Ghizal
Bahramsoltani, Roodabeh
Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
title Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
title_full Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
title_fullStr Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
title_full_unstemmed Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
title_short Citrus flavonoids and adhesion molecules: Potential role in the management of atherosclerosis
title_sort citrus flavonoids and adhesion molecules: potential role in the management of atherosclerosis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663934/
https://www.ncbi.nlm.nih.gov/pubmed/38028000
http://dx.doi.org/10.1016/j.heliyon.2023.e21849
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