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Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis

BACKGROUND: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predic...

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Autores principales: Buttery, Sara C., Williams, Parris J., Alghamdi, Saeed M., Philip, Keir E.J., Perkins, Alexis, Kallis, Constantinos, Quint, Jennifer K., Polkey, Michael I., Breuls, Sofie, Buekers, Joren, Chynkiamis, Nikolaos, Delgado-Ortiz, Laura, Demeyer, Heleen, Frei, Anja, Garcia-Aymerich, Judith, Gimeno-Santos, Elena, Koch, Sarah, Megaritis, Dimitrios, Polhemus, Ashley, Troosters, Thierry, Vogiatzis, Ioannis, Watz, Henrik, Hopkinson, Nicholas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663939/
https://www.ncbi.nlm.nih.gov/pubmed/37993126
http://dx.doi.org/10.1183/16000617.0134-2023
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author Buttery, Sara C.
Williams, Parris J.
Alghamdi, Saeed M.
Philip, Keir E.J.
Perkins, Alexis
Kallis, Constantinos
Quint, Jennifer K.
Polkey, Michael I.
Breuls, Sofie
Buekers, Joren
Chynkiamis, Nikolaos
Delgado-Ortiz, Laura
Demeyer, Heleen
Frei, Anja
Garcia-Aymerich, Judith
Gimeno-Santos, Elena
Koch, Sarah
Megaritis, Dimitrios
Polhemus, Ashley
Troosters, Thierry
Vogiatzis, Ioannis
Watz, Henrik
Hopkinson, Nicholas S.
author_facet Buttery, Sara C.
Williams, Parris J.
Alghamdi, Saeed M.
Philip, Keir E.J.
Perkins, Alexis
Kallis, Constantinos
Quint, Jennifer K.
Polkey, Michael I.
Breuls, Sofie
Buekers, Joren
Chynkiamis, Nikolaos
Delgado-Ortiz, Laura
Demeyer, Heleen
Frei, Anja
Garcia-Aymerich, Judith
Gimeno-Santos, Elena
Koch, Sarah
Megaritis, Dimitrios
Polhemus, Ashley
Troosters, Thierry
Vogiatzis, Ioannis
Watz, Henrik
Hopkinson, Nicholas S.
author_sort Buttery, Sara C.
collection PubMed
description BACKGROUND: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predictive value of these measures remains unclear in relation to key outcomes such as hospital admission and survival. METHODS: We conducted a systematic review, nested within a larger scoping review by the MOBILISE-D consortium, addressing DMOs in a range of chronic conditions. Qualitative and quantitative analysis considering steps per day and gait speed and their association with clinical outcomes in COPD patients was performed. RESULTS: 21 studies (6076 participants) were included. Nine studies evaluated steps per day and 11 evaluated a measure reflecting gait speed in daily life. Negative associations were demonstrated between mortality risk and steps per day (per 1000 steps) (hazard ratio (HR) 0.81, 95% CI 0.75–0.88, p<0.001), gait speed (<0.80 m·s(−1)) (HR 3.55, 95% CI 1.72–7.36, p<0.001) and gait speed (per 1.0 m·s(−1)) (HR 7.55, 95% CI 1.11–51.3, p=0.04). Fewer steps per day (per 1000) and slow gait speed (<0.80 m·s(−1)) were also associated with increased healthcare utilisation (HR 0.80, 95% CI 0.72–0.88, p<0.001; OR 3.36, 95% CI 1.42–7.94, p=0.01, respectively). Available evidence was of low-moderate quality with few studies eligible for meta-analysis. CONCLUSION: Daily step count and gait speed are negatively associated with mortality risk and other important outcomes in people with COPD and therefore may have value as prognostic indicators in clinical trials, but the quantity and quality of evidence is limited. Larger studies with consistent methodologies are called for.
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spelling pubmed-106639392023-11-22 Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis Buttery, Sara C. Williams, Parris J. Alghamdi, Saeed M. Philip, Keir E.J. Perkins, Alexis Kallis, Constantinos Quint, Jennifer K. Polkey, Michael I. Breuls, Sofie Buekers, Joren Chynkiamis, Nikolaos Delgado-Ortiz, Laura Demeyer, Heleen Frei, Anja Garcia-Aymerich, Judith Gimeno-Santos, Elena Koch, Sarah Megaritis, Dimitrios Polhemus, Ashley Troosters, Thierry Vogiatzis, Ioannis Watz, Henrik Hopkinson, Nicholas S. Eur Respir Rev Reviews BACKGROUND: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predictive value of these measures remains unclear in relation to key outcomes such as hospital admission and survival. METHODS: We conducted a systematic review, nested within a larger scoping review by the MOBILISE-D consortium, addressing DMOs in a range of chronic conditions. Qualitative and quantitative analysis considering steps per day and gait speed and their association with clinical outcomes in COPD patients was performed. RESULTS: 21 studies (6076 participants) were included. Nine studies evaluated steps per day and 11 evaluated a measure reflecting gait speed in daily life. Negative associations were demonstrated between mortality risk and steps per day (per 1000 steps) (hazard ratio (HR) 0.81, 95% CI 0.75–0.88, p<0.001), gait speed (<0.80 m·s(−1)) (HR 3.55, 95% CI 1.72–7.36, p<0.001) and gait speed (per 1.0 m·s(−1)) (HR 7.55, 95% CI 1.11–51.3, p=0.04). Fewer steps per day (per 1000) and slow gait speed (<0.80 m·s(−1)) were also associated with increased healthcare utilisation (HR 0.80, 95% CI 0.72–0.88, p<0.001; OR 3.36, 95% CI 1.42–7.94, p=0.01, respectively). Available evidence was of low-moderate quality with few studies eligible for meta-analysis. CONCLUSION: Daily step count and gait speed are negatively associated with mortality risk and other important outcomes in people with COPD and therefore may have value as prognostic indicators in clinical trials, but the quantity and quality of evidence is limited. Larger studies with consistent methodologies are called for. European Respiratory Society 2023-11-22 /pmc/articles/PMC10663939/ /pubmed/37993126 http://dx.doi.org/10.1183/16000617.0134-2023 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org
spellingShingle Reviews
Buttery, Sara C.
Williams, Parris J.
Alghamdi, Saeed M.
Philip, Keir E.J.
Perkins, Alexis
Kallis, Constantinos
Quint, Jennifer K.
Polkey, Michael I.
Breuls, Sofie
Buekers, Joren
Chynkiamis, Nikolaos
Delgado-Ortiz, Laura
Demeyer, Heleen
Frei, Anja
Garcia-Aymerich, Judith
Gimeno-Santos, Elena
Koch, Sarah
Megaritis, Dimitrios
Polhemus, Ashley
Troosters, Thierry
Vogiatzis, Ioannis
Watz, Henrik
Hopkinson, Nicholas S.
Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
title Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
title_full Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
title_fullStr Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
title_full_unstemmed Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
title_short Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
title_sort investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663939/
https://www.ncbi.nlm.nih.gov/pubmed/37993126
http://dx.doi.org/10.1183/16000617.0134-2023
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