Cargando…
Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis
BACKGROUND: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predic...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663939/ https://www.ncbi.nlm.nih.gov/pubmed/37993126 http://dx.doi.org/10.1183/16000617.0134-2023 |
_version_ | 1785148688126967808 |
---|---|
author | Buttery, Sara C. Williams, Parris J. Alghamdi, Saeed M. Philip, Keir E.J. Perkins, Alexis Kallis, Constantinos Quint, Jennifer K. Polkey, Michael I. Breuls, Sofie Buekers, Joren Chynkiamis, Nikolaos Delgado-Ortiz, Laura Demeyer, Heleen Frei, Anja Garcia-Aymerich, Judith Gimeno-Santos, Elena Koch, Sarah Megaritis, Dimitrios Polhemus, Ashley Troosters, Thierry Vogiatzis, Ioannis Watz, Henrik Hopkinson, Nicholas S. |
author_facet | Buttery, Sara C. Williams, Parris J. Alghamdi, Saeed M. Philip, Keir E.J. Perkins, Alexis Kallis, Constantinos Quint, Jennifer K. Polkey, Michael I. Breuls, Sofie Buekers, Joren Chynkiamis, Nikolaos Delgado-Ortiz, Laura Demeyer, Heleen Frei, Anja Garcia-Aymerich, Judith Gimeno-Santos, Elena Koch, Sarah Megaritis, Dimitrios Polhemus, Ashley Troosters, Thierry Vogiatzis, Ioannis Watz, Henrik Hopkinson, Nicholas S. |
author_sort | Buttery, Sara C. |
collection | PubMed |
description | BACKGROUND: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predictive value of these measures remains unclear in relation to key outcomes such as hospital admission and survival. METHODS: We conducted a systematic review, nested within a larger scoping review by the MOBILISE-D consortium, addressing DMOs in a range of chronic conditions. Qualitative and quantitative analysis considering steps per day and gait speed and their association with clinical outcomes in COPD patients was performed. RESULTS: 21 studies (6076 participants) were included. Nine studies evaluated steps per day and 11 evaluated a measure reflecting gait speed in daily life. Negative associations were demonstrated between mortality risk and steps per day (per 1000 steps) (hazard ratio (HR) 0.81, 95% CI 0.75–0.88, p<0.001), gait speed (<0.80 m·s(−1)) (HR 3.55, 95% CI 1.72–7.36, p<0.001) and gait speed (per 1.0 m·s(−1)) (HR 7.55, 95% CI 1.11–51.3, p=0.04). Fewer steps per day (per 1000) and slow gait speed (<0.80 m·s(−1)) were also associated with increased healthcare utilisation (HR 0.80, 95% CI 0.72–0.88, p<0.001; OR 3.36, 95% CI 1.42–7.94, p=0.01, respectively). Available evidence was of low-moderate quality with few studies eligible for meta-analysis. CONCLUSION: Daily step count and gait speed are negatively associated with mortality risk and other important outcomes in people with COPD and therefore may have value as prognostic indicators in clinical trials, but the quantity and quality of evidence is limited. Larger studies with consistent methodologies are called for. |
format | Online Article Text |
id | pubmed-10663939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-106639392023-11-22 Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis Buttery, Sara C. Williams, Parris J. Alghamdi, Saeed M. Philip, Keir E.J. Perkins, Alexis Kallis, Constantinos Quint, Jennifer K. Polkey, Michael I. Breuls, Sofie Buekers, Joren Chynkiamis, Nikolaos Delgado-Ortiz, Laura Demeyer, Heleen Frei, Anja Garcia-Aymerich, Judith Gimeno-Santos, Elena Koch, Sarah Megaritis, Dimitrios Polhemus, Ashley Troosters, Thierry Vogiatzis, Ioannis Watz, Henrik Hopkinson, Nicholas S. Eur Respir Rev Reviews BACKGROUND: Reduced mobility is a central feature of COPD. Assessment of mobility outcomes that can be measured digitally (digital mobility outcomes (DMOs)) in daily life such as gait speed and steps per day is increasingly possible using devices such as pedometers and accelerometers, but the predictive value of these measures remains unclear in relation to key outcomes such as hospital admission and survival. METHODS: We conducted a systematic review, nested within a larger scoping review by the MOBILISE-D consortium, addressing DMOs in a range of chronic conditions. Qualitative and quantitative analysis considering steps per day and gait speed and their association with clinical outcomes in COPD patients was performed. RESULTS: 21 studies (6076 participants) were included. Nine studies evaluated steps per day and 11 evaluated a measure reflecting gait speed in daily life. Negative associations were demonstrated between mortality risk and steps per day (per 1000 steps) (hazard ratio (HR) 0.81, 95% CI 0.75–0.88, p<0.001), gait speed (<0.80 m·s(−1)) (HR 3.55, 95% CI 1.72–7.36, p<0.001) and gait speed (per 1.0 m·s(−1)) (HR 7.55, 95% CI 1.11–51.3, p=0.04). Fewer steps per day (per 1000) and slow gait speed (<0.80 m·s(−1)) were also associated with increased healthcare utilisation (HR 0.80, 95% CI 0.72–0.88, p<0.001; OR 3.36, 95% CI 1.42–7.94, p=0.01, respectively). Available evidence was of low-moderate quality with few studies eligible for meta-analysis. CONCLUSION: Daily step count and gait speed are negatively associated with mortality risk and other important outcomes in people with COPD and therefore may have value as prognostic indicators in clinical trials, but the quantity and quality of evidence is limited. Larger studies with consistent methodologies are called for. European Respiratory Society 2023-11-22 /pmc/articles/PMC10663939/ /pubmed/37993126 http://dx.doi.org/10.1183/16000617.0134-2023 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org |
spellingShingle | Reviews Buttery, Sara C. Williams, Parris J. Alghamdi, Saeed M. Philip, Keir E.J. Perkins, Alexis Kallis, Constantinos Quint, Jennifer K. Polkey, Michael I. Breuls, Sofie Buekers, Joren Chynkiamis, Nikolaos Delgado-Ortiz, Laura Demeyer, Heleen Frei, Anja Garcia-Aymerich, Judith Gimeno-Santos, Elena Koch, Sarah Megaritis, Dimitrios Polhemus, Ashley Troosters, Thierry Vogiatzis, Ioannis Watz, Henrik Hopkinson, Nicholas S. Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
title | Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
title_full | Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
title_fullStr | Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
title_full_unstemmed | Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
title_short | Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
title_sort | investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663939/ https://www.ncbi.nlm.nih.gov/pubmed/37993126 http://dx.doi.org/10.1183/16000617.0134-2023 |
work_keys_str_mv | AT butterysarac investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT williamsparrisj investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT alghamdisaeedm investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT philipkeirej investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT perkinsalexis investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT kallisconstantinos investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT quintjenniferk investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT polkeymichaeli investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT breulssofie investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT buekersjoren investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT chynkiamisnikolaos investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT delgadoortizlaura investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT demeyerheleen investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT freianja investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT garciaaymerichjudith investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT gimenosantoselena investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT kochsarah investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT megaritisdimitrios investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT polhemusashley investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT troostersthierry investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT vogiatzisioannis investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT watzhenrik investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis AT hopkinsonnicholass investigatingtheprognosticvalueofdigitalmobilityoutcomesinpatientswithchronicobstructivepulmonarydiseaseasystematicliteraturereviewandmetaanalysis |