Cargando…

Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor, microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases, such as Alzheimer’s disease,...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Xiaoyan, Liu, Yi, Liu, Junlin, Zhang, Hantao, Shan, Chaofan, Guo, Yinglu, Gong, Xun, Cui, Mengmeng, Li, Xiubin, Tang, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664138/
https://www.ncbi.nlm.nih.gov/pubmed/37843219
http://dx.doi.org/10.4103/1673-5374.382223
_version_ 1785138551566893056
author Liu, Xiaoyan
Liu, Yi
Liu, Junlin
Zhang, Hantao
Shan, Chaofan
Guo, Yinglu
Gong, Xun
Cui, Mengmeng
Li, Xiubin
Tang, Min
author_facet Liu, Xiaoyan
Liu, Yi
Liu, Junlin
Zhang, Hantao
Shan, Chaofan
Guo, Yinglu
Gong, Xun
Cui, Mengmeng
Li, Xiubin
Tang, Min
author_sort Liu, Xiaoyan
collection PubMed
description A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor, microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms, and for both neuroimmune and neuroendocrine systems. Here, we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases, with an emphasis on multi-omics studies and the gut virome. The pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also elucidated. Finally, we discuss the role of diet, prebiotics, probiotics, postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases.
format Online
Article
Text
id pubmed-10664138
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-106641382023-08-14 Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence Liu, Xiaoyan Liu, Yi Liu, Junlin Zhang, Hantao Shan, Chaofan Guo, Yinglu Gong, Xun Cui, Mengmeng Li, Xiubin Tang, Min Neural Regen Res Review A growing body of evidence suggests that the gut microbiota contributes to the development of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor, microbiota dysbiosis always occurs in pathological changes of neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped to reveal that the bidirectional communication between the central nervous system and the enteric nervous system is facilitated by the microbiota’s diverse microorganisms, and for both neuroimmune and neuroendocrine systems. Here, we summarize the bioinformatics analysis and wet-biology validation for the gut metagenomics in neurodegenerative diseases, with an emphasis on multi-omics studies and the gut virome. The pathogen-associated signaling biomarkers for identifying brain disorders and potential therapeutic targets are also elucidated. Finally, we discuss the role of diet, prebiotics, probiotics, postbiotics and exercise interventions in remodeling the microbiome and reducing the symptoms of neurodegenerative diseases. Wolters Kluwer - Medknow 2023-08-14 /pmc/articles/PMC10664138/ /pubmed/37843219 http://dx.doi.org/10.4103/1673-5374.382223 Text en Copyright: © Neural Regeneration Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Liu, Xiaoyan
Liu, Yi
Liu, Junlin
Zhang, Hantao
Shan, Chaofan
Guo, Yinglu
Gong, Xun
Cui, Mengmeng
Li, Xiubin
Tang, Min
Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
title Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
title_full Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
title_fullStr Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
title_full_unstemmed Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
title_short Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
title_sort correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664138/
https://www.ncbi.nlm.nih.gov/pubmed/37843219
http://dx.doi.org/10.4103/1673-5374.382223
work_keys_str_mv AT liuxiaoyan correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT liuyi correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT liujunlin correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT zhanghantao correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT shanchaofan correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT guoyinglu correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT gongxun correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT cuimengmeng correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT lixiubin correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence
AT tangmin correlationbetweenthegutmicrobiomeandneurodegenerativediseasesareviewofmetagenomicsevidence