Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes

Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However, extending the clinical benefit to patients with other cancers poses a challenge. Inefficient costimulation in the tumor microenvironment can le...

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Detalles Bibliográficos
Autores principales: Kalaitsidou, Milena, Moon, Owen R., Sykorova, Martina, Bao, Leyuan, Qu, Yun, Sukumaran, Sujita, Valentine, Michael, Zhou, Xingliang, Pandey, Veethika, Foos, Kay, Medvedev, Sergey, Powell Jr, Daniel J., Udyavar, Akshata, Gschweng, Eric, Rodriguez, Ruben, Dudley, Mark E., Hawkins, Robert E., Kueberuwa, Gray, Bridgeman, John S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664248/
https://www.ncbi.nlm.nih.gov/pubmed/38022678
http://dx.doi.org/10.3389/fimmu.2023.1256491

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