Myrislignan targets extracellular signal-regulated kinase (ERK) and modulates mitochondrial function to dampen osteoclastogenesis and ovariectomy-induced osteoporosis

BACKGROUND: Activated osteoclasts cause excessive bone resorption, and disrupt bone homeostasis, leading to osteoporosis. The extracellular signal-regulated kinase (ERK) signaling is the classical pathway related to osteoclast differentiation, and mitochondrial reactive oxygen species are closely as...

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Detalles Bibliográficos
Autores principales: Yang, Tao, Chen, Weiwei, Gan, Kai, Wang, Chaofeng, Xie, Xiaoxiao, Su, Yuangang, Lian, Haoyu, Xu, Jiake, Zhao, Jinmin, Liu, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664306/
https://www.ncbi.nlm.nih.gov/pubmed/37993937
http://dx.doi.org/10.1186/s12967-023-04706-2

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