Massive underrepresentation of Arabs in genomic studies of common disease

Arabs represent 5% of the world population and have a high prevalence of common disease, yet remain greatly underrepresented in genome-wide association studies, where only 1 in 600 individuals are Arab. We highlight the persistent and unaddressed underrepresentation of Arabs in genomic databases and...

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Autores principales: Bhattacharya, Romit, Chen, NingNing, Shim, Injeong, Kuwahara, Hiroyuki, Gao, Xin, Alkuraya, Fowzan S., Fahed, Akl C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664351/
https://www.ncbi.nlm.nih.gov/pubmed/37993966
http://dx.doi.org/10.1186/s13073-023-01254-8
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author Bhattacharya, Romit
Chen, NingNing
Shim, Injeong
Kuwahara, Hiroyuki
Gao, Xin
Alkuraya, Fowzan S.
Fahed, Akl C.
author_facet Bhattacharya, Romit
Chen, NingNing
Shim, Injeong
Kuwahara, Hiroyuki
Gao, Xin
Alkuraya, Fowzan S.
Fahed, Akl C.
author_sort Bhattacharya, Romit
collection PubMed
description Arabs represent 5% of the world population and have a high prevalence of common disease, yet remain greatly underrepresented in genome-wide association studies, where only 1 in 600 individuals are Arab. We highlight the persistent and unaddressed underrepresentation of Arabs in genomic databases and discuss its impact on public health genomics and missed opportunities for biological discovery.
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spelling pubmed-106643512023-11-22 Massive underrepresentation of Arabs in genomic studies of common disease Bhattacharya, Romit Chen, NingNing Shim, Injeong Kuwahara, Hiroyuki Gao, Xin Alkuraya, Fowzan S. Fahed, Akl C. Genome Med Comment Arabs represent 5% of the world population and have a high prevalence of common disease, yet remain greatly underrepresented in genome-wide association studies, where only 1 in 600 individuals are Arab. We highlight the persistent and unaddressed underrepresentation of Arabs in genomic databases and discuss its impact on public health genomics and missed opportunities for biological discovery. BioMed Central 2023-11-22 /pmc/articles/PMC10664351/ /pubmed/37993966 http://dx.doi.org/10.1186/s13073-023-01254-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Comment
Bhattacharya, Romit
Chen, NingNing
Shim, Injeong
Kuwahara, Hiroyuki
Gao, Xin
Alkuraya, Fowzan S.
Fahed, Akl C.
Massive underrepresentation of Arabs in genomic studies of common disease
title Massive underrepresentation of Arabs in genomic studies of common disease
title_full Massive underrepresentation of Arabs in genomic studies of common disease
title_fullStr Massive underrepresentation of Arabs in genomic studies of common disease
title_full_unstemmed Massive underrepresentation of Arabs in genomic studies of common disease
title_short Massive underrepresentation of Arabs in genomic studies of common disease
title_sort massive underrepresentation of arabs in genomic studies of common disease
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664351/
https://www.ncbi.nlm.nih.gov/pubmed/37993966
http://dx.doi.org/10.1186/s13073-023-01254-8
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