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Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary

PURPOSE: The purpose of this study was to explore echocardiographic parameters of the left ventricle (LV) in relation to the outcomes of omphalocele neonates with pulmonary hypertension (PH). METHODS: This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. P...

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Autores principales: Yang, Si-Si, Huang, Wen-Chang, Wang, Peng, Gong, Fang-Qi, Liu, Tai-Xiang, Tou, Jin-Fa, Lai, Deng-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664469/
https://www.ncbi.nlm.nih.gov/pubmed/37990192
http://dx.doi.org/10.1186/s12887-023-04418-y
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author Yang, Si-Si
Huang, Wen-Chang
Wang, Peng
Gong, Fang-Qi
Liu, Tai-Xiang
Tou, Jin-Fa
Lai, Deng-Ming
author_facet Yang, Si-Si
Huang, Wen-Chang
Wang, Peng
Gong, Fang-Qi
Liu, Tai-Xiang
Tou, Jin-Fa
Lai, Deng-Ming
author_sort Yang, Si-Si
collection PubMed
description PURPOSE: The purpose of this study was to explore echocardiographic parameters of the left ventricle (LV) in relation to the outcomes of omphalocele neonates with pulmonary hypertension (PH). METHODS: This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have additional severe malformations or chromosomal aberrations. Patients who died under palliative care were excluded. The echocardiographic parameters of LV were obtained within 24 h after birth. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal dimension in end-diastole (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others. RESULTS: There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Both groups were comparable in the baseline characteristics. Non-survival was associated with a smaller LV [LVIDd (12.2 mm versus15.7 mm, p < 0.05), EDV (3.5 ml versus 6.8 ml, p < 0.05)] and with worse systolic function [SV (2.3 ml versus 4.2 ml, p < 0.05), and CI (1.7 L/min/m(2) versus 2.9 L/min/m(2), p < 0.01)]. CONCLUSION: In the cohort of omphalocele patients with PH, lower LVIDd, EDV, SV and CI were associated with mortality. LEVEL OF EVIDENCE: Level III.
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spelling pubmed-106644692023-11-22 Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary Yang, Si-Si Huang, Wen-Chang Wang, Peng Gong, Fang-Qi Liu, Tai-Xiang Tou, Jin-Fa Lai, Deng-Ming BMC Pediatr Research PURPOSE: The purpose of this study was to explore echocardiographic parameters of the left ventricle (LV) in relation to the outcomes of omphalocele neonates with pulmonary hypertension (PH). METHODS: This retrospective study was conducted among omphalocele patients with PH born from 2019 to 2020. Patients in this study did not have additional severe malformations or chromosomal aberrations. Patients who died under palliative care were excluded. The echocardiographic parameters of LV were obtained within 24 h after birth. Clinical and outcomes data were recorded, echocardiograms evaluated for left ventricular internal dimension in end-diastole (LVIDd), end-diastolic volume (EDV), stroke volume (SV) and cardiac output index (CI), among others. RESULTS: There were 18 omphalocele newborns with PH, of whom 14 survived and 4 died. Both groups were comparable in the baseline characteristics. Non-survival was associated with a smaller LV [LVIDd (12.2 mm versus15.7 mm, p < 0.05), EDV (3.5 ml versus 6.8 ml, p < 0.05)] and with worse systolic function [SV (2.3 ml versus 4.2 ml, p < 0.05), and CI (1.7 L/min/m(2) versus 2.9 L/min/m(2), p < 0.01)]. CONCLUSION: In the cohort of omphalocele patients with PH, lower LVIDd, EDV, SV and CI were associated with mortality. LEVEL OF EVIDENCE: Level III. BioMed Central 2023-11-22 /pmc/articles/PMC10664469/ /pubmed/37990192 http://dx.doi.org/10.1186/s12887-023-04418-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yang, Si-Si
Huang, Wen-Chang
Wang, Peng
Gong, Fang-Qi
Liu, Tai-Xiang
Tou, Jin-Fa
Lai, Deng-Ming
Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
title Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
title_full Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
title_fullStr Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
title_full_unstemmed Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
title_short Echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
title_sort echocardiographic measurements of left ventricular dimensions and function in newborns with omphalocele and pulmonary
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664469/
https://www.ncbi.nlm.nih.gov/pubmed/37990192
http://dx.doi.org/10.1186/s12887-023-04418-y
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