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How important is the linearity assumption in a sample size calculation for a randomised controlled trial where treatment is anticipated to affect a rate of change?

BACKGROUND: For certain conditions, treatments aim to lessen deterioration over time. A trial outcome could be change in a continuous measure, analysed using a random slopes model with a different slope in each treatment group. A sample size for a trial with a particular schedule of visits (e.g. ann...

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Detalles Bibliográficos
Autores principales:	Morgan, Katy E., White, Ian R., Frost, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664473/ https://www.ncbi.nlm.nih.gov/pubmed/37990159 http://dx.doi.org/10.1186/s12874-023-02093-2

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