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Stereoselective RNA reaction with chiral 2′-OH acylating agents

The reactivity of RNA 2′-OH groups with acylating agents has recently been investigated for high-yield conjugation of RNA strands. To date, only achiral molecules have been studied for this reaction, despite the complex chiral structure of RNA. Here we prepare a set of chiral acylimidazoles and stud...

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Detalles Bibliográficos
Autores principales: Shioi, Ryuta, Xiao, Lu, Chatterjee, Sayantan, Kool, Eric T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664579/
https://www.ncbi.nlm.nih.gov/pubmed/38023505
http://dx.doi.org/10.1039/d3sc03067a

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