Gold-catalyzed alkenylation and arylation of phosphorothioates

Reported herein is the ligand-enabled gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides. Mechanistic studies revealed a crucial role of the in situ generated Ag–sulfur complex, which undergoes a facile transmetalation with the Au(iii) intermediate, thereby...

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Detalles Bibliográficos
Autores principales: Urvashi, Mishra, Sampoorna, Patil, Nitin T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664589/
https://www.ncbi.nlm.nih.gov/pubmed/38023501
http://dx.doi.org/10.1039/d3sc04888h
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author Urvashi
Mishra, Sampoorna
Patil, Nitin T.
author_facet Urvashi
Mishra, Sampoorna
Patil, Nitin T.
author_sort Urvashi
collection PubMed
description Reported herein is the ligand-enabled gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides. Mechanistic studies revealed a crucial role of the in situ generated Ag–sulfur complex, which undergoes a facile transmetalation with the Au(iii) intermediate, thereby leading to the successful realization of the present reaction. Moreover, for the first time, the alkenylation of phosphoroselenoates under gold redox catalysis has been presented.
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spelling pubmed-106645892023-10-30 Gold-catalyzed alkenylation and arylation of phosphorothioates Urvashi Mishra, Sampoorna Patil, Nitin T. Chem Sci Chemistry Reported herein is the ligand-enabled gold-catalyzed alkenylation and arylation of phosphorothioates using alkenyl and aryl iodides. Mechanistic studies revealed a crucial role of the in situ generated Ag–sulfur complex, which undergoes a facile transmetalation with the Au(iii) intermediate, thereby leading to the successful realization of the present reaction. Moreover, for the first time, the alkenylation of phosphoroselenoates under gold redox catalysis has been presented. The Royal Society of Chemistry 2023-10-30 /pmc/articles/PMC10664589/ /pubmed/38023501 http://dx.doi.org/10.1039/d3sc04888h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Urvashi
Mishra, Sampoorna
Patil, Nitin T.
Gold-catalyzed alkenylation and arylation of phosphorothioates
title Gold-catalyzed alkenylation and arylation of phosphorothioates
title_full Gold-catalyzed alkenylation and arylation of phosphorothioates
title_fullStr Gold-catalyzed alkenylation and arylation of phosphorothioates
title_full_unstemmed Gold-catalyzed alkenylation and arylation of phosphorothioates
title_short Gold-catalyzed alkenylation and arylation of phosphorothioates
title_sort gold-catalyzed alkenylation and arylation of phosphorothioates
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664589/
https://www.ncbi.nlm.nih.gov/pubmed/38023501
http://dx.doi.org/10.1039/d3sc04888h
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AT mishrasampoorna goldcatalyzedalkenylationandarylationofphosphorothioates
AT patilnitint goldcatalyzedalkenylationandarylationofphosphorothioates

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