Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge

BACKGROUND: Microglia are increasingly understood to play an important role in the pathogenesis of Alzheimer’s disease. The rs75932628 (p.R47H) TREM2 variant is a well-established risk factor for Alzheimer’s disease. TREM2 is a microglial cell surface receptor. In this multi-modal/multi-tracer PET/M...

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Detalles Bibliográficos
Autores principales: Cousins, Oliver, Schubert, Julia J., Chandra, Avinash, Veronese, Mattia, Valkimadi, Polena, Creese, Byron, Khan, Zunera, Arathimos, Ryan, Hampshire, Adam, Rosenzweig, Ivana, Ballard, Clive, Corbett, Anne, Aasland, Dag, Velayudhan, Latha, O’Neill, Michael, Collier, David, Awais, Ramla, Sander, Kerstin, Årstad, Erik, Howes, Oliver, Turkheimer, Federico, Hodges, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664604/
https://www.ncbi.nlm.nih.gov/pubmed/37990275
http://dx.doi.org/10.1186/s12974-023-02945-0

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