Nuclear-cytoplasmic asynchrony in oocyte maturation caused by TUBB8 variants via impairing microtubule function: a novel pathogenic mechanism

BACKGROUND: TUBB8, a crucial gene encoding microtubule protein, plays a pivotal role in cellular processes. Deleterious TUBB8 variants have been shown to significantly hinder oocyte maturation. In this study, we conducted an in vitro investigation using TUBB8 mutant mouse oocytes to elucidate the pa...

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Detalles Bibliográficos
Autores principales: Chang, Tianli, Zhao, Jing, Li, Qi, Meng, Anning, Xia, Qiuping, Li, Yanping, Xiang, Wenpei, Yao, Zhongyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664611/
https://www.ncbi.nlm.nih.gov/pubmed/37993944
http://dx.doi.org/10.1186/s12958-023-01161-y

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