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A flexible dose-response modeling framework based on continuous toxicity outcomes in phase I cancer clinical trials
BACKGROUND: The past few decades have seen remarkable developments in dose-finding designs for phase I cancer clinical trials. While many of these designs rely on a binary toxicity response, there is an increasing focus on leveraging continuous toxicity responses. A continuous toxicity response pert...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664620/ https://www.ncbi.nlm.nih.gov/pubmed/37990281 http://dx.doi.org/10.1186/s13063-023-07793-0 |