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Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment

Lipid-structured vesicles have been applied for drug delivery system for over 50 years. Based on their origin, lipid-structured vesicles are divided into two main categories, namely synthetic lipid vesicles (SLNVEs) and vesicles of mammalian origin (MDVEs). Although SLNVEs can stably transport anti-...

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Autores principales: Zhao, Yuying, Tan, Hanxu, Zhang, Juping, Pan, Bo, Wang, Neng, Chen, Tongkai, Shi, Yafei, Wang, Zhiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664809/
https://www.ncbi.nlm.nih.gov/pubmed/38026523
http://dx.doi.org/10.2147/IJN.S432279
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author Zhao, Yuying
Tan, Hanxu
Zhang, Juping
Pan, Bo
Wang, Neng
Chen, Tongkai
Shi, Yafei
Wang, Zhiyu
author_facet Zhao, Yuying
Tan, Hanxu
Zhang, Juping
Pan, Bo
Wang, Neng
Chen, Tongkai
Shi, Yafei
Wang, Zhiyu
author_sort Zhao, Yuying
collection PubMed
description Lipid-structured vesicles have been applied for drug delivery system for over 50 years. Based on their origin, lipid-structured vesicles are divided into two main categories, namely synthetic lipid vesicles (SLNVEs) and vesicles of mammalian origin (MDVEs). Although SLNVEs can stably transport anti-cancer drugs, their biocompatibility is poor and degradation of exogenous substances is a potential risk. Unlike SLNVEs, MDVEs have excellent biocompatibility but are limited by a lack of stability and a risk of contamination by dangerous pathogens from donor cells. Since the first discovery of plant-derived vesicles (PDVEs) in carrot cell supernatants in 1967, emerging evidence has shown that PDVEs integrate the advantages of both SLNVEs and MDVEs. Notably, 55 years of dedicated research has indicated that PDVEs are an ideal candidate vesicle for drug preparation, transport, and disease treatment. The current review systematically focuses on the role of PDVEs in cancer therapy and in particular compares the properties of PDVEs with those of conventional lipid vesicles, summarizes the preparation methods and quality control of PDVEs, and discusses the application of PDVEs in delivering anti-cancer drugs and their underlying molecular mechanisms for cancer therapy. Finally, the challenges and future perspectives of PDVEs for the development of novel therapeutic strategies against cancer are discussed.
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spelling pubmed-106648092023-11-18 Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment Zhao, Yuying Tan, Hanxu Zhang, Juping Pan, Bo Wang, Neng Chen, Tongkai Shi, Yafei Wang, Zhiyu Int J Nanomedicine Review Lipid-structured vesicles have been applied for drug delivery system for over 50 years. Based on their origin, lipid-structured vesicles are divided into two main categories, namely synthetic lipid vesicles (SLNVEs) and vesicles of mammalian origin (MDVEs). Although SLNVEs can stably transport anti-cancer drugs, their biocompatibility is poor and degradation of exogenous substances is a potential risk. Unlike SLNVEs, MDVEs have excellent biocompatibility but are limited by a lack of stability and a risk of contamination by dangerous pathogens from donor cells. Since the first discovery of plant-derived vesicles (PDVEs) in carrot cell supernatants in 1967, emerging evidence has shown that PDVEs integrate the advantages of both SLNVEs and MDVEs. Notably, 55 years of dedicated research has indicated that PDVEs are an ideal candidate vesicle for drug preparation, transport, and disease treatment. The current review systematically focuses on the role of PDVEs in cancer therapy and in particular compares the properties of PDVEs with those of conventional lipid vesicles, summarizes the preparation methods and quality control of PDVEs, and discusses the application of PDVEs in delivering anti-cancer drugs and their underlying molecular mechanisms for cancer therapy. Finally, the challenges and future perspectives of PDVEs for the development of novel therapeutic strategies against cancer are discussed. Dove 2023-11-18 /pmc/articles/PMC10664809/ /pubmed/38026523 http://dx.doi.org/10.2147/IJN.S432279 Text en © 2023 Zhao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Zhao, Yuying
Tan, Hanxu
Zhang, Juping
Pan, Bo
Wang, Neng
Chen, Tongkai
Shi, Yafei
Wang, Zhiyu
Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
title Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
title_full Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
title_fullStr Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
title_full_unstemmed Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
title_short Plant-Derived Vesicles: A New Era for Anti-Cancer Drug Delivery and Cancer Treatment
title_sort plant-derived vesicles: a new era for anti-cancer drug delivery and cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664809/
https://www.ncbi.nlm.nih.gov/pubmed/38026523
http://dx.doi.org/10.2147/IJN.S432279
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