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Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements

Sustained pharyngeal inflation (SPI) with pharyngeal oxygen flow and nasal closure (PhO(2)-NC) technique create positive inflation pressure in the airway. This study measured the peak inflation pressure (PIP) levels and image changes with SPI-assisted flexible bronchoscopy (SPI-FB) and compared the...

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Autores principales: Soong, Christina, Lee, Yu-Sheng, Lin, Chien-Heng, Chen, Chieh-Ho, Soong, Wen-Jue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664907/
https://www.ncbi.nlm.nih.gov/pubmed/37992011
http://dx.doi.org/10.1371/journal.pone.0294029
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author Soong, Christina
Lee, Yu-Sheng
Lin, Chien-Heng
Chen, Chieh-Ho
Soong, Wen-Jue
author_facet Soong, Christina
Lee, Yu-Sheng
Lin, Chien-Heng
Chen, Chieh-Ho
Soong, Wen-Jue
author_sort Soong, Christina
collection PubMed
description Sustained pharyngeal inflation (SPI) with pharyngeal oxygen flow and nasal closure (PhO(2)-NC) technique create positive inflation pressure in the airway. This study measured the peak inflation pressure (PIP) levels and image changes with SPI-assisted flexible bronchoscopy (SPI-FB) and compared the effects in the pharyngeal space and mid-tracheal lumen. This prospective study enrolled 20 participants aged 6 months to 3 years. Each participant underwent sequential SPI-FB of four different durations (0, 1s, 3s, and 5s) for three cycles. We used a 3.8 mm OD flexible bronchoscope to measure and analyze PIP levels, images, and lumen dimension scores. A total of 480 data were collected. The mean (SD) age and body weight were 12.0 (11.5) months and 7.8 (7.5) kg, respectively. The mean (IQR) PIPs were 4.2 (2.0), 18.5 (6.1), 30.6 (13.5), and 46.1 (25.0) cmH(2)O in the pharynx and 5.0 (1.6), 17.5 (6.5), 28.0 (12.3), 46.0 (28.5) cmH(2)O in the mid-trachea at SPI durations of 0, 1s, 3s, and 5s, respectively. The PIP levels had a positive correlation (p <0.001) with different SPI durations in both pharynx and trachea, and were nearly identical (p = 0.695, 0.787, and 0.725 at 1s, 3s, and 5s, respectively) at the same duration except the 0 s (p = 0.015). Lumen dimension scores also significantly increased with increasing SPI durations (p <0.05) in both locations. The identified lesions significantly increased as PIP levels increased (p <0.001). Conclusion: SPI-FB using PhO(2)-NC with durations up to 3s is safe and informative technique that provides controllable PIP, dilates airway lumens, and benefits lesion detection in the pharyngeal space and mid-tracheal lumen.
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spelling pubmed-106649072023-11-22 Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements Soong, Christina Lee, Yu-Sheng Lin, Chien-Heng Chen, Chieh-Ho Soong, Wen-Jue PLoS One Research Article Sustained pharyngeal inflation (SPI) with pharyngeal oxygen flow and nasal closure (PhO(2)-NC) technique create positive inflation pressure in the airway. This study measured the peak inflation pressure (PIP) levels and image changes with SPI-assisted flexible bronchoscopy (SPI-FB) and compared the effects in the pharyngeal space and mid-tracheal lumen. This prospective study enrolled 20 participants aged 6 months to 3 years. Each participant underwent sequential SPI-FB of four different durations (0, 1s, 3s, and 5s) for three cycles. We used a 3.8 mm OD flexible bronchoscope to measure and analyze PIP levels, images, and lumen dimension scores. A total of 480 data were collected. The mean (SD) age and body weight were 12.0 (11.5) months and 7.8 (7.5) kg, respectively. The mean (IQR) PIPs were 4.2 (2.0), 18.5 (6.1), 30.6 (13.5), and 46.1 (25.0) cmH(2)O in the pharynx and 5.0 (1.6), 17.5 (6.5), 28.0 (12.3), 46.0 (28.5) cmH(2)O in the mid-trachea at SPI durations of 0, 1s, 3s, and 5s, respectively. The PIP levels had a positive correlation (p <0.001) with different SPI durations in both pharynx and trachea, and were nearly identical (p = 0.695, 0.787, and 0.725 at 1s, 3s, and 5s, respectively) at the same duration except the 0 s (p = 0.015). Lumen dimension scores also significantly increased with increasing SPI durations (p <0.05) in both locations. The identified lesions significantly increased as PIP levels increased (p <0.001). Conclusion: SPI-FB using PhO(2)-NC with durations up to 3s is safe and informative technique that provides controllable PIP, dilates airway lumens, and benefits lesion detection in the pharyngeal space and mid-tracheal lumen. Public Library of Science 2023-11-22 /pmc/articles/PMC10664907/ /pubmed/37992011 http://dx.doi.org/10.1371/journal.pone.0294029 Text en © 2023 Soong et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Soong, Christina
Lee, Yu-Sheng
Lin, Chien-Heng
Chen, Chieh-Ho
Soong, Wen-Jue
Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements
title Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements
title_full Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements
title_fullStr Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements
title_full_unstemmed Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements
title_short Sustained pharyngeal inflation in infant airway—Flexible bronchoscopy measurements
title_sort sustained pharyngeal inflation in infant airway—flexible bronchoscopy measurements
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664907/
https://www.ncbi.nlm.nih.gov/pubmed/37992011
http://dx.doi.org/10.1371/journal.pone.0294029
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