Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma

Osteosarcoma is a highly aggressive cancer and lacks effective therapeutic targets. We found that L3MBTL2 acts as a tumor suppressor by transcriptionally repressing IFIT2 in osteosarcoma. L3MBTL2 recruits the components of Polycomb repressive complex 1.6 to form condensates via both Pho-binding pock...

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Detalles Bibliográficos
Autores principales: Zhong, Li, Wang, Jingxuan, Chen, Wanqi, Lv, Dongming, Zhang, Ruhua, Wang, Xin, Zeng, Cuiling, He, Xiaobo, Zheng, Lisi, Gao, Ying, Wang, Shang, Li, Miao, Wu, Yuanzhong, Yin, Junqiang, Kang, Tiebang, Liao, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664996/
https://www.ncbi.nlm.nih.gov/pubmed/37992172
http://dx.doi.org/10.1126/sciadv.adi0889

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