RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS

Repulsive guidance molecule A (RGMa) was originally identified as a neuronal growth cone–collapsing factor. Previous reports have demonstrated the multifunctional roles of RGMa mediated by neogenin1. However, the pathogenic involvement of RGMa in amyotrophic lateral sclerosis (ALS) remains unclear....

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Detalles Bibliográficos
Autores principales: Shimizu, Mikito, Shiraishi, Naoyuki, Tada, Satoru, Sasaki, Tsutomu, Beck, Goichi, Nagano, Seiichi, Kinoshita, Makoto, Sumi, Hisae, Sugimoto, Tomoyuki, Ishida, Yoko, Koda, Toru, Ishikura, Teruyuki, Sugiyama, Yasuko, Kihara, Keigo, Kanakura, Minami, Nakajima, Tsuneo, Takeda, Shuko, Takahashi, Masanori P., Yamashita, Toshihide, Okuno, Tatsusada, Mochizuki, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665002/
https://www.ncbi.nlm.nih.gov/pubmed/37992159
http://dx.doi.org/10.1126/sciadv.adg3193

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