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Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)(1,2), conferring a predisposition to life-threatening COVID-19 pneumonia(3). Here we report that patients with autosomal...
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