Cargando…

Embryo-scale reverse genetics at single-cell resolution

The maturation of single-cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from whole embryos(1–4). A majority of these data, however, has been collected from wild-type embryos without an appreciation for the latent variation that is present in develop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Saunders, Lauren M., Srivatsan, Sanjay R., Duran, Madeleine, Dorrity, Michael W., Ewing, Brent, Linbo, Tor H., Shendure, Jay, Raible, David W., Moens, Cecilia B., Kimelman, David, Trapnell, Cole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665197/ https://www.ncbi.nlm.nih.gov/pubmed/37968389 http://dx.doi.org/10.1038/s41586-023-06720-2

Ejemplares similares

Dimensionality reduction by UMAP to visualize physical and genetic interactions
por: Dorrity, Michael W., et al.
Publicado: (2020)

Supervised classification enables rapid annotation of cell atlases
por: Pliner, Hannah A., et al.
Publicado: (2019)

Systematic reconstruction of cellular trajectories across mouse embryogenesis
por: Qiu, Chengxiang, et al.
Publicado: (2022)

High-Capacity Sample Multiplexing for Single Cell Chromatin Accessibility Profiling
por: Booth, Gregory T., et al.
Publicado: (2023)

High-capacity sample multiplexing for single cell chromatin accessibility profiling
por: Booth, Gregory T., et al.
Publicado: (2023)

Nuclear oligo hashing improves differential analysis of single-cell RNA-seq
por: Kim, Hyeon-Jin, et al.
Publicado: (2022)

Sci-fate characterizes the dynamics of gene expression in single cells
por: Cao, Junyue, et al.
Publicado: (2020)

Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy
por: McFaline-Figueroa, José L., et al.
Publicado: (2023)

Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish
por: Stawicki, Tamara M., et al.
Publicado: (2016)

A single-cell transcriptional timelapse of mouse embryonic development, from gastrula to pup
por: Qiu, Chengxiang, et al.
Publicado: (2023)

Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes
por: Shi, Tuo, et al.
Publicado: (2023)

Single-cell landscape of nuclear configuration and gene expression during stem cell differentiation and X inactivation
por: Bonora, Giancarlo, et al.
Publicado: (2021)

Single-cell, whole-embryo phenotyping of mammalian developmental disorders
por: Huang, Xingfan, et al.
Publicado: (2023)

The cis-regulatory dynamics of embryonic development at single cell resolution
por: Cusanovich, Darren A., et al.
Publicado: (2018)

Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana
por: Jean-Baptiste, Ken, et al.
Publicado: (2019)

The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function
por: Stawicki, Tamara M., et al.
Publicado: (2014)

The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death
por: Stawicki, Tamara M., et al.
Publicado: (2018)

Multipotent progenitors and hematopoietic stem cells arise independently from hemogenic endothelium in the mouse embryo
por: Dignum, Tessa, et al.
Publicado: (2021)

The landscape of alternative polyadenylation in single cells of the developing mouse embryo
por: Agarwal, Vikram, et al.
Publicado: (2021)

The continuum of Drosophila embryonic development at single-cell resolution
por: Calderon, Diego, et al.
Publicado: (2022)

Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells
por: Pickett, Sarah B, et al.
Publicado: (2018)

A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition
por: McFaline-Figueroa, José L., et al.
Publicado: (2019)

Generating Chimeric Zebrafish Embryos by Transplantation
por: Kemp, Hilary A., et al.
Publicado: (2009)

Loss of Slc4a1b Chloride/Bicarbonate Exchanger Function Protects Mechanosensory Hair Cells from Aminoglycoside Damage in the Zebrafish Mutant persephone
por: Hailey, Dale W., et al.
Publicado: (2012)

The regulatory landscape of Arabidopsis thaliana roots at single-cell resolution
por: Dorrity, Michael W., et al.
Publicado: (2021)

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death
por: Owens, Kelly N., et al.
Publicado: (2008)

Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo
por: Yoshimatsu, Takeshi, et al.
Publicado: (2016)

Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish
por: Rubin, Sara A., et al.
Publicado: (2022)

Predicting cellular responses to complex perturbations in high‐throughput screens
por: Lotfollahi, Mohammad, et al.
Publicado: (2023)

Pluripotent stem cell-derived model of the post-implantation human embryo
por: Weatherbee, Bailey A. T., et al.
Publicado: (2023)

Publisher Correction: Pluripotent stem cell-derived model of the post-implantation human embryo
por: Weatherbee, Bailey A. T., et al.
Publicado: (2023)

The C. elegans embryonic transcriptome with tissue, time, and alternative splicing resolution
por: Warner, Adam D., et al.
Publicado: (2019)

On the design of CRISPR-based single cell molecular screens
por: Hill, Andrew J., et al.
Publicado: (2018)

Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway
por: Larabell, Carolyn A., et al.
Publicado: (1997)

High-throughput identification of dominant negative polypeptides in yeast
por: Dorrity, Michael W., et al.
Publicado: (2019)

Defining cell types and states with single-cell genomics
por: Trapnell, Cole
Publicado: (2015)

The single cell transcriptional landscape of mammalian organogenesis
por: Cao, Junyue, et al.
Publicado: (2019)

The accessible chromatin landscape of the murine hippocampus at single-cell resolution
por: Sinnamon, John R., et al.
Publicado: (2019)

Embryo model completes gastrulation to neurulation and organogenesis
por: Amadei, Gianluca, et al.
Publicado: (2022)

Detection of minimal residual disease in NPM1-mutated acute myeloid leukemia by next-generation sequencing
por: Salipante, Stephen J., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_njedmet3qvb6t9noled9jk4pj5