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Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study
Parkinson’s disease (PD) and cardio-cerebrovascular diseases are related, according to earlier studies, but these studies have some controversy. Our aim was to assess the impact of PD on cardiocerebrovascular diseases using a Mendelian randomization (MR) method. The data for PD were single nucleotid...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665329/ https://www.ncbi.nlm.nih.gov/pubmed/37993489 http://dx.doi.org/10.1038/s41598-023-47708-2 |
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author | Zhou, Zhongzheng Zhang, Muzi Fang, Qinghua Huang, Jing |
author_facet | Zhou, Zhongzheng Zhang, Muzi Fang, Qinghua Huang, Jing |
author_sort | Zhou, Zhongzheng |
collection | PubMed |
description | Parkinson’s disease (PD) and cardio-cerebrovascular diseases are related, according to earlier studies, but these studies have some controversy. Our aim was to assess the impact of PD on cardiocerebrovascular diseases using a Mendelian randomization (MR) method. The data for PD were single nucleotide polymorphisms (SNPs) from a publicly available genome-wide association study (GWAS) dataset containing data on 482,730 individuals. And the outcome SNPs data is were derived from five different GWAS datasets. The basic method for MR analysis was the inverse variance weighted (IVW) approach. We use the weighted median method and the MR-Egger method to supplement the MR analysis conclusion. Finally, We used Cochran’s Q test to test heterogeneity, MR-PRESSO method and leave-one-out analysis method to perform sensitivity analysis. We used ratio ratios (OR) to assess the strength of the association between exposure and outcome, and 95% confidence intervals (CI) to show the reliability of the results. Our findings imply that PD is linked to a higher occurrence of coronary artery disease (CAD) (OR = 1.055, 95% CI 1.020–1.091, P = 0.001), stroke (OR = 1.039, 95% CI 1.007–1.072, P = 0.014). IVW analyses for stroke’s subgroups of ischemic stroke (IS) and 95% CI 1.007–1.072, P = 0.014). IVW analyses for stroke’s subgroups of ischemic stroke (IS) and cardioembolic stroke (CES) also yielded positive results, respectively (OR = 1.043, 95% CI 1.008–1.079, P = 0.013), (OR = 1.076, 95% CI 1.008–1.149, P = 0.026). There is no evidence of a relationship between PD and other cardio-cerebrovascular diseases. Additionally, sensitivity analysis revealed reliable outcomes. Our MR study analysis that PD is related with an elevated risk of CAD, stroke, IS, and CES. |
format | Online Article Text |
id | pubmed-10665329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-106653292023-11-22 Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study Zhou, Zhongzheng Zhang, Muzi Fang, Qinghua Huang, Jing Sci Rep Article Parkinson’s disease (PD) and cardio-cerebrovascular diseases are related, according to earlier studies, but these studies have some controversy. Our aim was to assess the impact of PD on cardiocerebrovascular diseases using a Mendelian randomization (MR) method. The data for PD were single nucleotide polymorphisms (SNPs) from a publicly available genome-wide association study (GWAS) dataset containing data on 482,730 individuals. And the outcome SNPs data is were derived from five different GWAS datasets. The basic method for MR analysis was the inverse variance weighted (IVW) approach. We use the weighted median method and the MR-Egger method to supplement the MR analysis conclusion. Finally, We used Cochran’s Q test to test heterogeneity, MR-PRESSO method and leave-one-out analysis method to perform sensitivity analysis. We used ratio ratios (OR) to assess the strength of the association between exposure and outcome, and 95% confidence intervals (CI) to show the reliability of the results. Our findings imply that PD is linked to a higher occurrence of coronary artery disease (CAD) (OR = 1.055, 95% CI 1.020–1.091, P = 0.001), stroke (OR = 1.039, 95% CI 1.007–1.072, P = 0.014). IVW analyses for stroke’s subgroups of ischemic stroke (IS) and 95% CI 1.007–1.072, P = 0.014). IVW analyses for stroke’s subgroups of ischemic stroke (IS) and cardioembolic stroke (CES) also yielded positive results, respectively (OR = 1.043, 95% CI 1.008–1.079, P = 0.013), (OR = 1.076, 95% CI 1.008–1.149, P = 0.026). There is no evidence of a relationship between PD and other cardio-cerebrovascular diseases. Additionally, sensitivity analysis revealed reliable outcomes. Our MR study analysis that PD is related with an elevated risk of CAD, stroke, IS, and CES. Nature Publishing Group UK 2023-11-22 /pmc/articles/PMC10665329/ /pubmed/37993489 http://dx.doi.org/10.1038/s41598-023-47708-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhou, Zhongzheng Zhang, Muzi Fang, Qinghua Huang, Jing Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study |
title | Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study |
title_full | Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study |
title_fullStr | Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study |
title_full_unstemmed | Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study |
title_short | Relationship between Parkinson’s disease and cardio-cerebrovascular diseases: a Mendelian randomized study |
title_sort | relationship between parkinson’s disease and cardio-cerebrovascular diseases: a mendelian randomized study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665329/ https://www.ncbi.nlm.nih.gov/pubmed/37993489 http://dx.doi.org/10.1038/s41598-023-47708-2 |
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