NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma

Few prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a prognostic marker for patients with lung squamous cell carcinoma. Shorter survival periods and tumor growth were linked to high NP...

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Autores principales: Wang, Naixue, Zhu, Dantong, Liu, Yao, Wu, Jingran, Wang, Meiling, Jin, Shanxiu, Fu, Fangwei, Li, Baolei, Ji, Hongjuan, Du, Cheng, Zheng, Zhendong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665339/
https://www.ncbi.nlm.nih.gov/pubmed/37993584
http://dx.doi.org/10.1038/s41598-023-47782-6
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author Wang, Naixue
Zhu, Dantong
Liu, Yao
Wu, Jingran
Wang, Meiling
Jin, Shanxiu
Fu, Fangwei
Li, Baolei
Ji, Hongjuan
Du, Cheng
Zheng, Zhendong
author_facet Wang, Naixue
Zhu, Dantong
Liu, Yao
Wu, Jingran
Wang, Meiling
Jin, Shanxiu
Fu, Fangwei
Li, Baolei
Ji, Hongjuan
Du, Cheng
Zheng, Zhendong
author_sort Wang, Naixue
collection PubMed
description Few prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a prognostic marker for patients with lung squamous cell carcinoma. Shorter survival periods and tumor growth were linked to high NPLOC4 expression.Disulfiram (DSF) combined with copper (Cu) targets NPLOC4 to achieve antitumor effects in lung squamous cell carcinoma. Thus, we investigated the effects of DSF with Cu in LUSC. Gene-set enrichment analysis identified ubiquitin-mediated proteolysis as the NPLOC4-associated mechanism influencing LUSC prognosis. In SK-MES-1 cell lines, DSF + Cu increased K48-linked ubiquitinated protein expression and apoptosis. This study identified NPLOC4 as a prognostic biomarker and a potential therapeutic target for LUSC.
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spelling pubmed-106653392023-11-22 NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma Wang, Naixue Zhu, Dantong Liu, Yao Wu, Jingran Wang, Meiling Jin, Shanxiu Fu, Fangwei Li, Baolei Ji, Hongjuan Du, Cheng Zheng, Zhendong Sci Rep Article Few prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a prognostic marker for patients with lung squamous cell carcinoma. Shorter survival periods and tumor growth were linked to high NPLOC4 expression.Disulfiram (DSF) combined with copper (Cu) targets NPLOC4 to achieve antitumor effects in lung squamous cell carcinoma. Thus, we investigated the effects of DSF with Cu in LUSC. Gene-set enrichment analysis identified ubiquitin-mediated proteolysis as the NPLOC4-associated mechanism influencing LUSC prognosis. In SK-MES-1 cell lines, DSF + Cu increased K48-linked ubiquitinated protein expression and apoptosis. This study identified NPLOC4 as a prognostic biomarker and a potential therapeutic target for LUSC. Nature Publishing Group UK 2023-11-22 /pmc/articles/PMC10665339/ /pubmed/37993584 http://dx.doi.org/10.1038/s41598-023-47782-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wang, Naixue
Zhu, Dantong
Liu, Yao
Wu, Jingran
Wang, Meiling
Jin, Shanxiu
Fu, Fangwei
Li, Baolei
Ji, Hongjuan
Du, Cheng
Zheng, Zhendong
NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
title NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
title_full NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
title_fullStr NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
title_full_unstemmed NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
title_short NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
title_sort nploc4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665339/
https://www.ncbi.nlm.nih.gov/pubmed/37993584
http://dx.doi.org/10.1038/s41598-023-47782-6
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