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The BRD4-SRPK2-SRSF2 signal modulates the splicing efficiency of ACSL3 pre-mRNA and influences erastin-induced ferroptosis in osteosarcoma cells

Lipid metabolism is the key to ferroptosis susceptibility. However, little is known about the underlying mechanisms in osteosarcoma cells. Functional restriction of bromodomain-containing protein 4 (BRD4) reduced the susceptibility to erastin-induced ferroptosis of osteosarcoma cells both in vitro a...

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Detalles Bibliográficos
Autores principales:	Luo, Shun-Hong, Tian, Jia-Ming, Chu, Yi, Zhu, Hong-Yi, Ni, Jiang-Dong, Huang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665344/ https://www.ncbi.nlm.nih.gov/pubmed/37993451 http://dx.doi.org/10.1038/s41419-023-06273-2

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