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Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells

Several chemotherapeutic drugs induce senescence in cancer cells; however, the mechanisms underlying intracellular pH dysregulation in senescent cells remain unclear. Adenosine triphosphatase H(+) transporting accessory protein 2 (ATP6AP2) plays a critical role in maintaining pH homeostasis in cellu...

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Detalles Bibliográficos
Autores principales:	Li, Wei, Kawaguchi, Kosuke, Tanaka, Sunao, He, Chenfeng, Maeshima, Yurina, Suzuki, Eiji, Toi, Masakazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665353/ https://www.ncbi.nlm.nih.gov/pubmed/37993606 http://dx.doi.org/10.1038/s42003-023-05433-6

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