A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

p53-mediated cell cycle arrest during DNA damage is dependent on the induction of p21 protein, encoded by the CDKN1A gene. p21 inhibits cyclin-dependent kinases required for cell cycle progression to guarantee accurate repair of DNA lesions. Hence, fine-tuning of p21 levels is crucial to preserve ge...

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Detalles Bibliográficos
Autores principales: Ben-Oz, Bella M., Machour, Feras E., Nicola, Marian, Argoetti, Amir, Polyak, Galia, Hanna, Rawad, Kleifeld, Oded, Mandel-Gutfreund, Yael, Ayoub, Nabieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665399/
https://www.ncbi.nlm.nih.gov/pubmed/37993446
http://dx.doi.org/10.1038/s41467-023-43495-6

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