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Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation

Deficits in spatial memory are often early signs of neurological disorders. Here, we analyzed the geometrical shape configuration of 2D-projections of pointing performances to a memorized array of spatially distributed targets in order to assess the feasibility of this new holistic analysis method....

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Autores principales: Gerb, J., Brandt, T., Dieterich, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665407/
https://www.ncbi.nlm.nih.gov/pubmed/37993521
http://dx.doi.org/10.1038/s41598-023-47821-2
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author Gerb, J.
Brandt, T.
Dieterich, M.
author_facet Gerb, J.
Brandt, T.
Dieterich, M.
author_sort Gerb, J.
collection PubMed
description Deficits in spatial memory are often early signs of neurological disorders. Here, we analyzed the geometrical shape configuration of 2D-projections of pointing performances to a memorized array of spatially distributed targets in order to assess the feasibility of this new holistic analysis method. The influence of gender differences and cognitive impairment was taken into account in this methodological study. 56 right-handed healthy participants (28 female, mean age 48.89 ± 19.35 years) and 22 right-handed patients with heterogeneous cognitive impairment (12 female, mean age 71.73 ± 7.41 years) underwent a previously validated 3D-real-world pointing test (3D-RWPT). Participants were shown a 9-dot target matrix and afterwards asked to point towards each target in randomized order with closed eyes in different body positions relative to the matrix. Two-dimensional projections of these pointing vectors (i.e., the shapes resulting from the individual dots) were then quantified using morphological analyses. Shape configurations in healthy volunteers largely reflected the real-world target pattern with gender-dependent differences (ANCOVA area males vs. females F(1,73) = 9.00, p 3.69 × 10(−3), partial η(2) = 0.10, post-hoc difference = 38,350.43, p(bonf=)3.69 × 10(−3)**, Cohen’s d 0.76, t 3.00). Patients with cognitive impairment showed distorted rectangularity with more large-scale errors, resulting in decreased overall average diameters and solidity (ANCOVA diameter normal cognition/cognitive impairment F(1,71) = 9.30, p 3.22 × 10(−3), partial η(2) = 0.09, post-hoc difference = 31.22, p(bonf=)3.19 × 10(−3)**, Cohen’s d 0.92, t 3.05; solidity normal cognition/cognitive impairment F(1,71) = 7.79, p 6.75 × 10(−3), partial η(2) = 0.08, post-hoc difference = 0.07, p(bonf=)6.76 × 10(−3)** Cohen’s d 0.84, t 2.79). Shape configuration analysis of the 3D-RWPT target array appears to be a suitable holistic measure of spatial performance in a pointing task. The results of this methodological investigation support further testing in a clinical study for differential diagnosis of disorders with spatial memory deficits.
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spelling pubmed-106654072023-11-22 Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation Gerb, J. Brandt, T. Dieterich, M. Sci Rep Article Deficits in spatial memory are often early signs of neurological disorders. Here, we analyzed the geometrical shape configuration of 2D-projections of pointing performances to a memorized array of spatially distributed targets in order to assess the feasibility of this new holistic analysis method. The influence of gender differences and cognitive impairment was taken into account in this methodological study. 56 right-handed healthy participants (28 female, mean age 48.89 ± 19.35 years) and 22 right-handed patients with heterogeneous cognitive impairment (12 female, mean age 71.73 ± 7.41 years) underwent a previously validated 3D-real-world pointing test (3D-RWPT). Participants were shown a 9-dot target matrix and afterwards asked to point towards each target in randomized order with closed eyes in different body positions relative to the matrix. Two-dimensional projections of these pointing vectors (i.e., the shapes resulting from the individual dots) were then quantified using morphological analyses. Shape configurations in healthy volunteers largely reflected the real-world target pattern with gender-dependent differences (ANCOVA area males vs. females F(1,73) = 9.00, p 3.69 × 10(−3), partial η(2) = 0.10, post-hoc difference = 38,350.43, p(bonf=)3.69 × 10(−3)**, Cohen’s d 0.76, t 3.00). Patients with cognitive impairment showed distorted rectangularity with more large-scale errors, resulting in decreased overall average diameters and solidity (ANCOVA diameter normal cognition/cognitive impairment F(1,71) = 9.30, p 3.22 × 10(−3), partial η(2) = 0.09, post-hoc difference = 31.22, p(bonf=)3.19 × 10(−3)**, Cohen’s d 0.92, t 3.05; solidity normal cognition/cognitive impairment F(1,71) = 7.79, p 6.75 × 10(−3), partial η(2) = 0.08, post-hoc difference = 0.07, p(bonf=)6.76 × 10(−3)** Cohen’s d 0.84, t 2.79). Shape configuration analysis of the 3D-RWPT target array appears to be a suitable holistic measure of spatial performance in a pointing task. The results of this methodological investigation support further testing in a clinical study for differential diagnosis of disorders with spatial memory deficits. Nature Publishing Group UK 2023-11-22 /pmc/articles/PMC10665407/ /pubmed/37993521 http://dx.doi.org/10.1038/s41598-023-47821-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Gerb, J.
Brandt, T.
Dieterich, M.
Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation
title Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation
title_full Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation
title_fullStr Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation
title_full_unstemmed Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation
title_short Shape configuration of mental targets representation as a holistic measure in a 3D real world pointing test for spatial orientation
title_sort shape configuration of mental targets representation as a holistic measure in a 3d real world pointing test for spatial orientation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665407/
https://www.ncbi.nlm.nih.gov/pubmed/37993521
http://dx.doi.org/10.1038/s41598-023-47821-2
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