Recent Advances in Bioorthogonal Ligation and Bioconjugation

The desire to create biomolecules modified with functionalities that go beyond nature’s toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconj...

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Detalles Bibliográficos
Autores principales: Zielke, Florian M., Rutjes, Floris P. J. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665463/
https://www.ncbi.nlm.nih.gov/pubmed/37991570
http://dx.doi.org/10.1007/s41061-023-00445-6
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author Zielke, Florian M.
Rutjes, Floris P. J. T.
author_facet Zielke, Florian M.
Rutjes, Floris P. J. T.
author_sort Zielke, Florian M.
collection PubMed
description The desire to create biomolecules modified with functionalities that go beyond nature’s toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules.
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spelling pubmed-106654632023-11-22 Recent Advances in Bioorthogonal Ligation and Bioconjugation Zielke, Florian M. Rutjes, Floris P. J. T. Top Curr Chem (Cham) Review The desire to create biomolecules modified with functionalities that go beyond nature’s toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules. Springer International Publishing 2023-11-22 2023 /pmc/articles/PMC10665463/ /pubmed/37991570 http://dx.doi.org/10.1007/s41061-023-00445-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zielke, Florian M.
Rutjes, Floris P. J. T.
Recent Advances in Bioorthogonal Ligation and Bioconjugation
title Recent Advances in Bioorthogonal Ligation and Bioconjugation
title_full Recent Advances in Bioorthogonal Ligation and Bioconjugation
title_fullStr Recent Advances in Bioorthogonal Ligation and Bioconjugation
title_full_unstemmed Recent Advances in Bioorthogonal Ligation and Bioconjugation
title_short Recent Advances in Bioorthogonal Ligation and Bioconjugation
title_sort recent advances in bioorthogonal ligation and bioconjugation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665463/
https://www.ncbi.nlm.nih.gov/pubmed/37991570
http://dx.doi.org/10.1007/s41061-023-00445-6
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