ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation

Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD). Mutations in the CCNF gene, encoding cyclin F, are present in both sporadic and familial ALS and FTD. However, the pathophysiological...

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Detalles Bibliográficos
Autores principales: Ragagnin, Audrey M. G., Sundaramoorthy, Vinod, Farzana, Fabiha, Gautam, Shashi, Saravanabavan, Sayanthooran, Takalloo, Zeinab, Mehta, Prachi, Do-Ha, Dzung, Parakh, Sonam, Shadfar, Sina, Hunter, Julie, Vidal, Marta, Jagaraj, Cyril J., Brocardo, Mariana, Konopka, Anna, Yang, Shu, Rayner, Stephanie L., Williams, Kelly L., Blair, Ian P., Chung, Roger S., Lee, Albert, Ooi, Lezanne, Atkin, Julie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665471/
https://www.ncbi.nlm.nih.gov/pubmed/37993492
http://dx.doi.org/10.1038/s41598-023-46802-9

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