P2X(7) accelerate tissue fibrosis via metalloproteinase 8‐dependent macrophage infiltration in a murine model of unilateral ureteral obstruction

Renal fibrosis is tightly associated with chronic kidney disease, irrespective of the underlying pathogenesis. We previously demonstrated mild antifibrotic effects of targeting the P2X(7) receptor in a pyelonephritis model. Reduced P2X(7)R‐activation elevated the neutrophil‐to‐macrophage ratio, resu...

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Detalles Bibliográficos
Autores principales: Therkildsen, Jacob Rudjord, Tingskov, Stine Julie, Jensen, Michael Schou, Praetorius, Helle, Nørregaard, Rikke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665779/
https://www.ncbi.nlm.nih.gov/pubmed/37994252
http://dx.doi.org/10.14814/phy2.15878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665779/
https://www.ncbi.nlm.nih.gov/pubmed/37994252
http://dx.doi.org/10.14814/phy2.15878

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