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Crosstalk: keratinocytes and immune cells in psoriasis

In the past, psoriasis was considered a skin disease caused only by keratinocyte disorders. However, the efficacy of immunosuppressive drugs and biologics used to treat psoriasis proves that psoriasis is an immune-mediated disease. Indeed, a variety of immune cells are involved in the pathogenesis o...

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Detalles Bibliográficos
Autores principales: Kamata, Masahiro, Tada, Yayoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665858/
https://www.ncbi.nlm.nih.gov/pubmed/38022549
http://dx.doi.org/10.3389/fimmu.2023.1286344
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author Kamata, Masahiro
Tada, Yayoi
author_facet Kamata, Masahiro
Tada, Yayoi
author_sort Kamata, Masahiro
collection PubMed
description In the past, psoriasis was considered a skin disease caused only by keratinocyte disorders. However, the efficacy of immunosuppressive drugs and biologics used to treat psoriasis proves that psoriasis is an immune-mediated disease. Indeed, a variety of immune cells are involved in the pathogenesis of psoriasis, including dendritic cells, Th17 cells, and resident memory T cells. Furthermore, keratinocytes play a role in the development of psoriasis as immune cells by secreting antibacterial peptides, chemokines, tumor necrosis factor-α, interleukin (IL)-36, and IL-23. These immune cells and skin cells interact and drive the aberrant differentiation and proliferation of keratinocytes. This crosstalk between keratinocytes and immune cells critical in the pathogenesis of psoriasis forms an inflammatory loop, resulting in the persistence or exacerbation of psoriasis plaques.
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spelling pubmed-106658582023-01-01 Crosstalk: keratinocytes and immune cells in psoriasis Kamata, Masahiro Tada, Yayoi Front Immunol Immunology In the past, psoriasis was considered a skin disease caused only by keratinocyte disorders. However, the efficacy of immunosuppressive drugs and biologics used to treat psoriasis proves that psoriasis is an immune-mediated disease. Indeed, a variety of immune cells are involved in the pathogenesis of psoriasis, including dendritic cells, Th17 cells, and resident memory T cells. Furthermore, keratinocytes play a role in the development of psoriasis as immune cells by secreting antibacterial peptides, chemokines, tumor necrosis factor-α, interleukin (IL)-36, and IL-23. These immune cells and skin cells interact and drive the aberrant differentiation and proliferation of keratinocytes. This crosstalk between keratinocytes and immune cells critical in the pathogenesis of psoriasis forms an inflammatory loop, resulting in the persistence or exacerbation of psoriasis plaques. Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10665858/ /pubmed/38022549 http://dx.doi.org/10.3389/fimmu.2023.1286344 Text en Copyright © 2023 Kamata and Tada https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kamata, Masahiro
Tada, Yayoi
Crosstalk: keratinocytes and immune cells in psoriasis
title Crosstalk: keratinocytes and immune cells in psoriasis
title_full Crosstalk: keratinocytes and immune cells in psoriasis
title_fullStr Crosstalk: keratinocytes and immune cells in psoriasis
title_full_unstemmed Crosstalk: keratinocytes and immune cells in psoriasis
title_short Crosstalk: keratinocytes and immune cells in psoriasis
title_sort crosstalk: keratinocytes and immune cells in psoriasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665858/
https://www.ncbi.nlm.nih.gov/pubmed/38022549
http://dx.doi.org/10.3389/fimmu.2023.1286344
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