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Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation

INTRODUCTION: Phagocytosis of inhaled crystalline silica (cSiO(2)) particles by tissue-resident alveolar macrophages (AMs) initiates generation of proinflammatory eicosanoids derived from the ω-6 polyunsaturated fatty acid (PUFA) arachidonic acid (ARA) that contribute to chronic inflammatory disease...

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Detalles Bibliográficos
Autores principales:	Favor, Olivia K., Rajasinghe, Lichchavi D., Wierenga, Kathryn A., Maddipati, Krishna R., Lee, Kin Sing Stephen, Olive, Andrew J., Pestka, James J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665862/ https://www.ncbi.nlm.nih.gov/pubmed/38022527 http://dx.doi.org/10.3389/fimmu.2023.1274147

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