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Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665873/ https://www.ncbi.nlm.nih.gov/pubmed/38026940 http://dx.doi.org/10.3389/fphar.2023.1287234 |
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author | Lv, Shimeng Zhang, Guangheng Huang, Yufei Li, Jiamin Yang, Ni Lu, Yitong Ma, Haoteng Ma, Yuexiang Teng, Jing |
author_facet | Lv, Shimeng Zhang, Guangheng Huang, Yufei Li, Jiamin Yang, Ni Lu, Yitong Ma, Haoteng Ma, Yuexiang Teng, Jing |
author_sort | Lv, Shimeng |
collection | PubMed |
description | The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channels, and compounds, exhibit immense potential in treating depression. Autophagy, a vital process in depression pathology, has emerged as a promising target for intervention. This review summarized the pharmacological mechanisms of antidepressants by regulating autophagy. We presented insights from recent studies, discussed current research limitations, and proposed new strategies for basic research and their clinical application in depression. |
format | Online Article Text |
id | pubmed-10665873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106658732023-11-09 Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy Lv, Shimeng Zhang, Guangheng Huang, Yufei Li, Jiamin Yang, Ni Lu, Yitong Ma, Haoteng Ma, Yuexiang Teng, Jing Front Pharmacol Pharmacology The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channels, and compounds, exhibit immense potential in treating depression. Autophagy, a vital process in depression pathology, has emerged as a promising target for intervention. This review summarized the pharmacological mechanisms of antidepressants by regulating autophagy. We presented insights from recent studies, discussed current research limitations, and proposed new strategies for basic research and their clinical application in depression. Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10665873/ /pubmed/38026940 http://dx.doi.org/10.3389/fphar.2023.1287234 Text en Copyright © 2023 Lv, Zhang, Huang, Li, Yang, Lu, Ma, Ma and Teng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Lv, Shimeng Zhang, Guangheng Huang, Yufei Li, Jiamin Yang, Ni Lu, Yitong Ma, Haoteng Ma, Yuexiang Teng, Jing Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
title | Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
title_full | Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
title_fullStr | Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
title_full_unstemmed | Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
title_short | Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
title_sort | antidepressant pharmacological mechanisms: focusing on the regulation of autophagy |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665873/ https://www.ncbi.nlm.nih.gov/pubmed/38026940 http://dx.doi.org/10.3389/fphar.2023.1287234 |
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