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Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy

The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channe...

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Autores principales: Lv, Shimeng, Zhang, Guangheng, Huang, Yufei, Li, Jiamin, Yang, Ni, Lu, Yitong, Ma, Haoteng, Ma, Yuexiang, Teng, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665873/
https://www.ncbi.nlm.nih.gov/pubmed/38026940
http://dx.doi.org/10.3389/fphar.2023.1287234
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author Lv, Shimeng
Zhang, Guangheng
Huang, Yufei
Li, Jiamin
Yang, Ni
Lu, Yitong
Ma, Haoteng
Ma, Yuexiang
Teng, Jing
author_facet Lv, Shimeng
Zhang, Guangheng
Huang, Yufei
Li, Jiamin
Yang, Ni
Lu, Yitong
Ma, Haoteng
Ma, Yuexiang
Teng, Jing
author_sort Lv, Shimeng
collection PubMed
description The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channels, and compounds, exhibit immense potential in treating depression. Autophagy, a vital process in depression pathology, has emerged as a promising target for intervention. This review summarized the pharmacological mechanisms of antidepressants by regulating autophagy. We presented insights from recent studies, discussed current research limitations, and proposed new strategies for basic research and their clinical application in depression.
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spelling pubmed-106658732023-11-09 Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy Lv, Shimeng Zhang, Guangheng Huang, Yufei Li, Jiamin Yang, Ni Lu, Yitong Ma, Haoteng Ma, Yuexiang Teng, Jing Front Pharmacol Pharmacology The core symptoms of depression are anhedonia and persistent hopelessness. Selective serotonin reuptake inhibitors (SSRIs) and their related medications are commonly used for clinical treatment, despite their significant adverse effects. Traditional Chinese medicine with its multiple targets, channels, and compounds, exhibit immense potential in treating depression. Autophagy, a vital process in depression pathology, has emerged as a promising target for intervention. This review summarized the pharmacological mechanisms of antidepressants by regulating autophagy. We presented insights from recent studies, discussed current research limitations, and proposed new strategies for basic research and their clinical application in depression. Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10665873/ /pubmed/38026940 http://dx.doi.org/10.3389/fphar.2023.1287234 Text en Copyright © 2023 Lv, Zhang, Huang, Li, Yang, Lu, Ma, Ma and Teng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lv, Shimeng
Zhang, Guangheng
Huang, Yufei
Li, Jiamin
Yang, Ni
Lu, Yitong
Ma, Haoteng
Ma, Yuexiang
Teng, Jing
Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
title Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
title_full Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
title_fullStr Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
title_full_unstemmed Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
title_short Antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
title_sort antidepressant pharmacological mechanisms: focusing on the regulation of autophagy
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665873/
https://www.ncbi.nlm.nih.gov/pubmed/38026940
http://dx.doi.org/10.3389/fphar.2023.1287234
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