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Early detection of type 2 diabetes risk: limitations of current diagnostic criteria

Type 2 diabetes (T2D) is the leading cause of diabetes worldwide and is increasing rapidly, especially in youth. It accounts for most diabetes deaths in adults ≥20 years old in the Americas, with type 2 diabetes responsible for most of the disease burden. The incidence and burden of type 2 diabetes...

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Autores principales: Zhang, Jiale, Zhang, Zhuoya, Zhang, Kaiqi, Ge, Xiaolei, Sun, Ranran, Zhai, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665905/
https://www.ncbi.nlm.nih.gov/pubmed/38027114
http://dx.doi.org/10.3389/fendo.2023.1260623
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author Zhang, Jiale
Zhang, Zhuoya
Zhang, Kaiqi
Ge, Xiaolei
Sun, Ranran
Zhai, Xu
author_facet Zhang, Jiale
Zhang, Zhuoya
Zhang, Kaiqi
Ge, Xiaolei
Sun, Ranran
Zhai, Xu
author_sort Zhang, Jiale
collection PubMed
description Type 2 diabetes (T2D) is the leading cause of diabetes worldwide and is increasing rapidly, especially in youth. It accounts for most diabetes deaths in adults ≥20 years old in the Americas, with type 2 diabetes responsible for most of the disease burden. The incidence and burden of type 2 diabetes in adolescents and young adults have risen in recent decades globally. Countries with lower socioeconomic status had the highest incidence and burden, and females generally had higher mortality and disease burden than males at ages <30 years. Early diagnosis and management are crucial to delaying progression, but current diagnostic criteria based on glucose thresholds and glycated hemoglobin have limitations. Recent analyses show that prediabetes increases cancer risk. Better diagnostic criteria are urgently needed to identify high-risk individuals earlier. This article discusses the limitations of current criteria and explores alternative approaches and future research directions.
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spelling pubmed-106659052023-01-01 Early detection of type 2 diabetes risk: limitations of current diagnostic criteria Zhang, Jiale Zhang, Zhuoya Zhang, Kaiqi Ge, Xiaolei Sun, Ranran Zhai, Xu Front Endocrinol (Lausanne) Endocrinology Type 2 diabetes (T2D) is the leading cause of diabetes worldwide and is increasing rapidly, especially in youth. It accounts for most diabetes deaths in adults ≥20 years old in the Americas, with type 2 diabetes responsible for most of the disease burden. The incidence and burden of type 2 diabetes in adolescents and young adults have risen in recent decades globally. Countries with lower socioeconomic status had the highest incidence and burden, and females generally had higher mortality and disease burden than males at ages <30 years. Early diagnosis and management are crucial to delaying progression, but current diagnostic criteria based on glucose thresholds and glycated hemoglobin have limitations. Recent analyses show that prediabetes increases cancer risk. Better diagnostic criteria are urgently needed to identify high-risk individuals earlier. This article discusses the limitations of current criteria and explores alternative approaches and future research directions. Frontiers Media S.A. 2023-11-09 /pmc/articles/PMC10665905/ /pubmed/38027114 http://dx.doi.org/10.3389/fendo.2023.1260623 Text en Copyright © 2023 Zhang, Zhang, Zhang, Ge, Sun and Zhai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Zhang, Jiale
Zhang, Zhuoya
Zhang, Kaiqi
Ge, Xiaolei
Sun, Ranran
Zhai, Xu
Early detection of type 2 diabetes risk: limitations of current diagnostic criteria
title Early detection of type 2 diabetes risk: limitations of current diagnostic criteria
title_full Early detection of type 2 diabetes risk: limitations of current diagnostic criteria
title_fullStr Early detection of type 2 diabetes risk: limitations of current diagnostic criteria
title_full_unstemmed Early detection of type 2 diabetes risk: limitations of current diagnostic criteria
title_short Early detection of type 2 diabetes risk: limitations of current diagnostic criteria
title_sort early detection of type 2 diabetes risk: limitations of current diagnostic criteria
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665905/
https://www.ncbi.nlm.nih.gov/pubmed/38027114
http://dx.doi.org/10.3389/fendo.2023.1260623
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