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The Origin and Fate of Liver Myofibroblasts

Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is caused by fibrogenic myofibroblasts that are not pr...

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Autores principales: Kim, Hyun Young, Sakane, Sadatsugu, Eguileor, Alvaro, Carvalho Gontijo Weber, Raquel, Lee, Wonseok, Liu, Xiao, Lam, Kevin, Ishizuka, Kei, Rosenthal, Sara Brin, Diggle, Karin, Brenner, David A., Kisseleva, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665929/
https://www.ncbi.nlm.nih.gov/pubmed/37743012
http://dx.doi.org/10.1016/j.jcmgh.2023.09.008
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author Kim, Hyun Young
Sakane, Sadatsugu
Eguileor, Alvaro
Carvalho Gontijo Weber, Raquel
Lee, Wonseok
Liu, Xiao
Lam, Kevin
Ishizuka, Kei
Rosenthal, Sara Brin
Diggle, Karin
Brenner, David A.
Kisseleva, Tatiana
author_facet Kim, Hyun Young
Sakane, Sadatsugu
Eguileor, Alvaro
Carvalho Gontijo Weber, Raquel
Lee, Wonseok
Liu, Xiao
Lam, Kevin
Ishizuka, Kei
Rosenthal, Sara Brin
Diggle, Karin
Brenner, David A.
Kisseleva, Tatiana
author_sort Kim, Hyun Young
collection PubMed
description Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is caused by fibrogenic myofibroblasts that are not present in the normal liver, but rather activate from liver resident mesenchymal cells in response to chronic toxic or cholestatic injury. Many studies indicate that liver fibrosis is reversible when the causative agent is removed. Regression of liver fibrosis is associated with the disappearance of activated myofibroblasts and resorption of the fibrous scar. In this review, we discuss the results of genetic tracing and cell fate mapping of hepatic stellate cells and portal fibroblasts, their specific characteristics, and potential phenotypes. We summarize research progress in the understanding of the molecular mechanisms underlying the development and reversibility of liver fibrosis, including activation, apoptosis, and inactivation of myofibroblasts.
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spelling pubmed-106659292023-09-22 The Origin and Fate of Liver Myofibroblasts Kim, Hyun Young Sakane, Sadatsugu Eguileor, Alvaro Carvalho Gontijo Weber, Raquel Lee, Wonseok Liu, Xiao Lam, Kevin Ishizuka, Kei Rosenthal, Sara Brin Diggle, Karin Brenner, David A. Kisseleva, Tatiana Cell Mol Gastroenterol Hepatol Review Liver fibrosis of different etiologies is a serious health problem worldwide. There is no effective therapy available for liver fibrosis except the removal of the underlying cause of injury or liver transplantation. Development of liver fibrosis is caused by fibrogenic myofibroblasts that are not present in the normal liver, but rather activate from liver resident mesenchymal cells in response to chronic toxic or cholestatic injury. Many studies indicate that liver fibrosis is reversible when the causative agent is removed. Regression of liver fibrosis is associated with the disappearance of activated myofibroblasts and resorption of the fibrous scar. In this review, we discuss the results of genetic tracing and cell fate mapping of hepatic stellate cells and portal fibroblasts, their specific characteristics, and potential phenotypes. We summarize research progress in the understanding of the molecular mechanisms underlying the development and reversibility of liver fibrosis, including activation, apoptosis, and inactivation of myofibroblasts. Elsevier 2023-09-22 /pmc/articles/PMC10665929/ /pubmed/37743012 http://dx.doi.org/10.1016/j.jcmgh.2023.09.008 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Kim, Hyun Young
Sakane, Sadatsugu
Eguileor, Alvaro
Carvalho Gontijo Weber, Raquel
Lee, Wonseok
Liu, Xiao
Lam, Kevin
Ishizuka, Kei
Rosenthal, Sara Brin
Diggle, Karin
Brenner, David A.
Kisseleva, Tatiana
The Origin and Fate of Liver Myofibroblasts
title The Origin and Fate of Liver Myofibroblasts
title_full The Origin and Fate of Liver Myofibroblasts
title_fullStr The Origin and Fate of Liver Myofibroblasts
title_full_unstemmed The Origin and Fate of Liver Myofibroblasts
title_short The Origin and Fate of Liver Myofibroblasts
title_sort origin and fate of liver myofibroblasts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665929/
https://www.ncbi.nlm.nih.gov/pubmed/37743012
http://dx.doi.org/10.1016/j.jcmgh.2023.09.008
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