A peptidomimetic modulator of the Ca(V)2.2 N-type calcium channel for chronic pain

Transmembrane Ca(v)2.2 (N-type) voltage-gated calcium channels are genetically and pharmacologically validated, clinically relevant pain targets. Clinical block of Ca(v)2.2 (e.g., with Prialt/Ziconotide) or indirect modulation [e.g., with gabapentinoids such as Gabapentin (GBP)] mitigates chronic pa...

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Detalles Bibliográficos
Autores principales: Gomez, Kimberly, Santiago, Ulises, Nelson, Tyler S., Allen, Heather N., Calderon-Rivera, Aida, Hestehave, Sara, Rodríguez Palma, Erick J., Zhou, Yuan, Duran, Paz, Loya-Lopez, Santiago, Zhu, Elaine, Kumar, Upasana, Shields, Rory, Koseli, Eda, McKiver, Bryan, Giuvelis, Denise, Zuo, Wanhong, Inyang, Kufreobong E., Dorame, Angie, Chefdeville, Aude, Ran, Dongzhi, Perez-Miller, Samantha, Lu, Yi, Liu, Xia, Handoko, Arora, Paramjit S., Patek, Marcel, Moutal, Aubin, Khanna, May, Hu, Huijuan, Laumet, Geoffroy, King, Tamara, Wang, Jing, Damaj, M. Imad, Korczeniewska, Olga A., Camacho, Carlos J., Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666126/
https://www.ncbi.nlm.nih.gov/pubmed/37972067
http://dx.doi.org/10.1073/pnas.2305215120

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