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Current trends of clinical trials involving CRISPR/Cas systems

The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous impacts on next-generation molecular diagnostics and therapeutics, especially for genetic disorders that traditional therapies cannot cure. Currently, CRISPR-based gene editing is widely applied in basic, preclinical, an...

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Autores principales: Zhang, Songyang, Wang, Yidi, Mao, Dezhi, Wang, Yue, Zhang, Hong, Pan, Yihan, Wang, Yuezeng, Teng, Shuzhi, Huang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666174/
https://www.ncbi.nlm.nih.gov/pubmed/38020120
http://dx.doi.org/10.3389/fmed.2023.1292452
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author Zhang, Songyang
Wang, Yidi
Mao, Dezhi
Wang, Yue
Zhang, Hong
Pan, Yihan
Wang, Yuezeng
Teng, Shuzhi
Huang, Ping
author_facet Zhang, Songyang
Wang, Yidi
Mao, Dezhi
Wang, Yue
Zhang, Hong
Pan, Yihan
Wang, Yuezeng
Teng, Shuzhi
Huang, Ping
author_sort Zhang, Songyang
collection PubMed
description The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous impacts on next-generation molecular diagnostics and therapeutics, especially for genetic disorders that traditional therapies cannot cure. Currently, CRISPR-based gene editing is widely applied in basic, preclinical, and clinical studies. In this review, we attempt to identify trends in clinical studies involving CRISPR techniques to gain insights into the improvement and contribution of CRISPR/Cas technologies compared to traditional modified modalities. The review of clinical trials is focused on the applications of the CRISPR/Cas systems in the treatment of cancer, hematological, endocrine, and immune system diseases, as well as in diagnostics. The scientific basis underlined is analyzed. In addition, the challenges of CRISPR application in disease therapies and recent advances that expand and improve CRISPR applications in precision medicine are discussed.
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spelling pubmed-106661742023-11-10 Current trends of clinical trials involving CRISPR/Cas systems Zhang, Songyang Wang, Yidi Mao, Dezhi Wang, Yue Zhang, Hong Pan, Yihan Wang, Yuezeng Teng, Shuzhi Huang, Ping Front Med (Lausanne) Medicine The CRISPR/Cas9 system is a powerful genome editing tool that has made enormous impacts on next-generation molecular diagnostics and therapeutics, especially for genetic disorders that traditional therapies cannot cure. Currently, CRISPR-based gene editing is widely applied in basic, preclinical, and clinical studies. In this review, we attempt to identify trends in clinical studies involving CRISPR techniques to gain insights into the improvement and contribution of CRISPR/Cas technologies compared to traditional modified modalities. The review of clinical trials is focused on the applications of the CRISPR/Cas systems in the treatment of cancer, hematological, endocrine, and immune system diseases, as well as in diagnostics. The scientific basis underlined is analyzed. In addition, the challenges of CRISPR application in disease therapies and recent advances that expand and improve CRISPR applications in precision medicine are discussed. Frontiers Media S.A. 2023-11-10 /pmc/articles/PMC10666174/ /pubmed/38020120 http://dx.doi.org/10.3389/fmed.2023.1292452 Text en Copyright © 2023 Zhang, Wang, Mao, Wang, Zhang, Pan, Wang, Teng and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Songyang
Wang, Yidi
Mao, Dezhi
Wang, Yue
Zhang, Hong
Pan, Yihan
Wang, Yuezeng
Teng, Shuzhi
Huang, Ping
Current trends of clinical trials involving CRISPR/Cas systems
title Current trends of clinical trials involving CRISPR/Cas systems
title_full Current trends of clinical trials involving CRISPR/Cas systems
title_fullStr Current trends of clinical trials involving CRISPR/Cas systems
title_full_unstemmed Current trends of clinical trials involving CRISPR/Cas systems
title_short Current trends of clinical trials involving CRISPR/Cas systems
title_sort current trends of clinical trials involving crispr/cas systems
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666174/
https://www.ncbi.nlm.nih.gov/pubmed/38020120
http://dx.doi.org/10.3389/fmed.2023.1292452
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